Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA.
Gynecol Obstet Invest. 2010;70(2):76-81. doi: 10.1159/000291287. Epub 2010 Mar 9.
Cryopreservation of all embryos in stimulated IVF cycles is occasionally necessary. Although it is known that frozen embryo transfer results in lower live birth rates per transfer, there is limited information regarding expected cumulative live birth rates for patients who are in this particular scenario.
The objective was to evaluate long-term outcomes in cycles undergoing pronuclear cryopreservation of all embryos utilizing a retrospective analysis of 154 consecutive recipients from 1995 to 2006.
The cumulative rate of first live birth per retrieval was 66.2%, with a 36.4% live birth rate per frozen embryo transfer. Following an average 2.2 +/- 0.98 transfers, 32.6% (17/52) of patients who never delivered had remaining embryos making the cumulative first live birth rate previously stated a conservative estimate. 11.7% of recipients had sibling deliveries from a single retrieval. Over 1/3 of the delivered recipients have remaining cryopreserved embryos and could pursue an additional pregnancy.
These results suggest that pronuclear cryopreservation of all embryos in an oocyte donation cycle maintains good cumulative live birth rates, as well as chances for a sibling from a single retrieval. Recipients who must delay transfer can be reassured a high potential for live birth from their first donor retrieval.
在体外受精（IVF）刺激周期中，偶尔需要对所有胚胎进行冷冻保存。虽然已知冷冻胚胎移植每次移植的活产率较低，但对于处于这种特殊情况的患者，预计累积活产率的相关信息有限。
本研究的目的是通过对 1995 年至 2006 年 154 名连续接受者进行回顾性分析，评估行原核冷冻保存所有胚胎的周期的长期结局。
每个取卵周期的首次活产率累积率为 66.2%，每个冷冻胚胎移植的活产率为 36.4%。平均进行 2.2+/-0.98 次移植后，从未分娩的 52 名患者中有 32.6%（17/52）剩余胚胎，这使得之前陈述的首次活产率成为保守估计。11.7%的接受者从单次取卵中获得了同胞分娩。超过三分之一的分娩接受者仍有冷冻保存的胚胎，可以继续进行另一次妊娠。
这些结果表明，在卵母细胞捐赠周期中对所有胚胎行原核冷冻保存可以保持良好的累积活产率，并且单次取卵即可获得同胞的机会。必须延迟移植的接受者可以放心，从首次供体取卵中获得活产的可能性很高。
