Servei de Medicina de la Reproducció, Departament d'Obstetrícia, Ginecologia i Reproducció, Institut Universitari Dexeus, Barcelona, Spain.
Reprod Biomed Online. 2012 Dec;25(6):642-8. doi: 10.1016/j.rbmo.2012.09.008. Epub 2012 Sep 21.
The aim of this study is to compare the cumulative clinical pregnancy and live birth rates (fresh embryo transfers followed by frozen-thawed embryo transfers from the same stimulated cycle) between single-embryo transfer (SET) and double-embryo transfer (DET) in an oocyte donation programme. A retrospective analysis of the outcome in 1139 recipient fresh cycles (1073 from DET and 66 from SET) with at least three available embryos for transfer was performed. The clinical pregnancy rates were similar after SET (45.5%, 30/66) and DET (57.1%, 613/1073), whereas the multiple pregnancy rate was 0% and 39.5% for SET and DET, respectively. After evaluating the results using the Kaplan-Meier survival analysis in a period of 1 year, no statistically significant differences were observed in the cumulative clinical pregnancy and live birth rates (SET 82.8% and 76.4% versus DET 77.2% and 63.7%). The results indicate that for women who have at least three available embryos in oocyte donation programmes, one single embryo should be transferred as no significant decrease in the success rate is observed and multiple pregnancy can be avoided. Clinical pregnancy rate is higher when transferring two embryos compared with one. However, this also results in a higher incidence of twin pregnancy, which is associated with increased obstetric and perinatal risks. The aim of this study was to compare the cumulative clinical pregnancy and live birth rates (fresh embryo transfers followed by frozen-thawed embryo transfers from the same stimulated cycle) between single-embryo transfer (SET) and double-embryo transfer (DET) cycles in our oocyte donation programme. A retrospective analysis of the outcome in 1139 recipient fresh cycles (1076 from DET and 66 from SET) with at least three available embryos for transfer was performed. The clinical pregnancy rates were similar after SET (45.5%, 30/66) and DET (57.1%, 613/1073), whereas the multiple pregnancy rate was 0% and 39.5% for SET and DET, respectively. The cumulative clinical pregnancy and live birth rates were similar between the two strategies (SET 82.8% versus DET 77.2%) and the same was found for the cumulative live birth rates (SET 76.4% versus DET 63.7%). Our results indicate that for women who have at least three available embryos in OD programmes, one single embryo should be transferred as no significant decrease in the success rate is observed while multiple pregnancy is avoided.
本研究旨在比较卵母细胞捐赠计划中单胚胎移植（SET）和双胚胎移植（DET）在新鲜胚胎移植（随后进行同一刺激周期的冷冻-解冻胚胎移植）后的累积临床妊娠率和活产率。对 1139 个接受新鲜周期治疗（DET 为 1076 个，SET 为 66 个）且至少有 3 个胚胎可供移植的患者的结局进行了回顾性分析。SET（45.5%，30/66）和 DET（57.1%，613/1073）后的临床妊娠率相似，而 SET 和 DET 的多胎妊娠率分别为 0%和 39.5%。在 1 年的时间内，使用 Kaplan-Meier 生存分析评估结果后，在累积临床妊娠率和活产率方面，SET（82.8%和 76.4%）与 DET（77.2%和 63.7%）之间没有观察到统计学显著差异。结果表明，对于卵母细胞捐赠计划中至少有 3 个胚胎的女性，应仅移植一个单胚胎，因为没有观察到成功率的显著下降，并且可以避免多胎妊娠。与移植一个胚胎相比，移植两个胚胎可提高临床妊娠率。然而，这也会导致双胞胎妊娠的发生率增加，这与增加的产科和围产期风险相关。本研究旨在比较我们的卵母细胞捐赠计划中单胚胎移植（SET）和双胚胎移植（DET）周期的累积临床妊娠率和活产率。对 1139 个接受新鲜周期治疗（DET 为 1076 个，SET 为 66 个）且至少有 3 个胚胎可供移植的患者的结局进行了回顾性分析。SET（45.5%，30/66）和 DET（57.1%，613/1073）后的临床妊娠率相似，而 SET 和 DET 的多胎妊娠率分别为 0%和 39.5%。两种策略的累积临床妊娠率和活产率相似（SET 82.8%与 DET 77.2%），累积活产率也相似（SET 76.4%与 DET 63.7%）。我们的结果表明，对于卵母细胞捐赠计划中至少有 3 个胚胎的女性，应仅移植一个单胚胎，因为没有观察到成功率的显著下降，同时可以避免多胎妊娠。
