高活动和低活动近交系小鼠的体力活动和食物消耗。
Physical activity and food consumption in high- and low-active inbred mouse strains.
机构信息
Department of Exercise Science and Sports Medicine, Samford University, Birmingham, AL 35229, USA.
出版信息
Med Sci Sports Exerc. 2010 Oct;42(10):1826-33. doi: 10.1249/MSS.0b013e3181daf5e8.
PURPOSE
To determine the effect of innate activity level and running wheel access on food consumption in high-active (SWR/J) low-active (DBA/2J) mice.
METHODS
Two strains of inbred mice were used in this study owing to their high activity level (SWR/J) and low activity level (DBA/2J). Mice were housed in individual cages, and half of the mice in each strain had free access to running wheels in their cages, whereas the other half received no running wheel. All mice consumed standard chow and water ad libitum for 13 wk during the study period. Running wheel activity (daily), food consumption (biweekly), and body mass (weekly) were recorded.
RESULTS
SWR/J runners consumed more food (6.0 ± 0.4 g·d)(-1) than SWR/J nonrunners (4.7 ± 0.2 g·d(-1), P = 0.03), DBA/2J runners (4.6 ± 0.2 g·d(-1), P = 0.02), and DBA/2J nonrunners (4.2 ± 0.2 g·d(-1), P = 0.006). SWR/J nonrunners consumed more food than DBA/2J nonrunners (P = 0.03). Average daily distance and duration were significantly greater for the SWR/J runners (6.4 ± 0.7 km·d(-1) and 333.6 ± 40.5 min·d(-1), respectively) compared with those for the DBA/2J runners (1.6 ± 0.4 km·d(-1) and 91.3 ± 23.0 min·d(-1), respectively). There was a significant correlation between food consumption and distance (r = 0.74, P < 0.001), duration (r = 0.68, P < 0.001), and speed (r = 0.58, P < 0.001), respectively, in all mice. However, when considering the individuals strains, the relationship between running wheel activity and food consumption was only statistically significant for the SWR/J mice.
CONCLUSIONS
Higher running wheel activity in mice was associated with increased food consumption in the SWR/J mice but not in the DBA/2J mice. In DBA/2J mice, addition of a running wheel did not result in increased food consumption, suggesting that energy expenditure of nonwheel cage activity in the control DBA/2J mice was similar to the energy expenditure of the wheel activity because body mass was similar between the two groups.
目的
确定先天活动水平和跑轮的可及性对高活性（SWR/J）和低活性（DBA/2J）小鼠食物消耗的影响。
方法
本研究使用两种近交系小鼠，因其具有高活动水平（SWR/J）和低活动水平（DBA/2J）。将小鼠单独饲养在笼子中，每只品系的一半小鼠在笼子中可自由使用跑轮，另一半则没有跑轮。在研究期间，所有小鼠均可自由摄入标准食物和水。记录跑轮活动（每日）、食物消耗（每两周）和体重（每周）。
结果
SWR/J 跑轮组小鼠的食物摄入量（6.0 ± 0.4 g·d）(-1)高于 SWR/J 非跑轮组（4.7 ± 0.2 g·d）(-1)（P = 0.03）、DBA/2J 跑轮组（4.6 ± 0.2 g·d）(-1)（P = 0.02）和 DBA/2J 非跑轮组（4.2 ± 0.2 g·d）(-1)（P = 0.006）。SWR/J 非跑轮组小鼠的食物摄入量高于 DBA/2J 非跑轮组（P = 0.03）。SWR/J 跑轮组小鼠的平均日活动距离和持续时间（分别为 6.4 ± 0.7 km·d）(-1)和 333.6 ± 40.5 min·d）(-1)明显大于 DBA/2J 跑轮组（分别为 1.6 ± 0.4 km·d）(-1)和 91.3 ± 23.0 min·d）(-1)（P 值分别为<0.001 和 <0.001）。所有小鼠的食物摄入量与距离（r = 0.74，P < 0.001）、持续时间（r = 0.68，P < 0.001）和速度（r = 0.58，P < 0.001）呈显著正相关。然而，当考虑到个体品系时，SWR/J 小鼠的跑轮活动与食物消耗之间的关系仅具有统计学意义，而 DBA/2J 小鼠则没有。在 DBA/2J 小鼠中，添加跑轮并没有导致食物摄入量增加，这表明对照组 DBA/2J 小鼠的非轮笼活动的能量消耗与轮活动的能量消耗相似，因为两组的体重相似。
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