Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sex Transm Dis. 2010 Apr;37(4):248-52. doi: 10.1097/OLQ.0b013e3181d4f866.
Population-based studies suggest that acquisition of herpes simplex virus 2 (HSV 2) is most common between ages 20 and 29, especially in minority women. We examined HSV 2 infection and viral shedding in a cohort of young women.
Women, age 18 to 24 (median 21), who were part of an observational cohort enrolled between ages 14 to 17, had blood obtained for HSV 2 antibody. Intensive diary collections on sexual behavior and genital symptoms and weekly vaginal swabs were obtained at regular intervals.
HSV 2 antibodies were detected in 43 of 127 participants (33.9%), only 4 of whom were previously known to be positive. Factors associated with a positive test included older age, years of sexual activity, and number of lifetime partners. Testing for HSV 2 DNA by polymerase chain reaction on weekly vaginal swabs from a 13-week sampling period for each HSV 2 antibody positive participant showed 32 of 43 (74.4%) were positive at least once. The positive predictive value of pain for viral shedding was poor.
HSV 2 infection is very common among young adult women, but symptomatic genital herpes is not. Shedding of HSV 2 DNA can be detected in most antibody positive persons. Early intervention strategies will be needed to control HSV 2 infection.
基于人群的研究表明，单纯疱疹病毒 2（HSV 2）的感染在 20 至 29 岁之间最为常见，尤其是少数族裔女性。我们检查了一组年轻女性的 HSV 2 感染和病毒脱落情况。
年龄在 18 至 24 岁之间（中位数 21 岁）的女性，是在 14 至 17 岁之间入组的观察性队列的一部分，她们接受了 HSV 2 抗体的血液检测。在定期间隔内，对性行为和生殖器症状进行了密集的日记记录，并每周采集阴道拭子。
在 127 名参与者中的 43 名（33.9%）检测到 HSV 2 抗体，其中只有 4 名以前已知为阳性。阳性检测结果与年龄较大、性活跃年限和性伴侣人数有关。对 13 周采样期间每周阴道拭子进行 HSV 2 DNA 的聚合酶链反应检测，结果显示 43 名 HSV 2 抗体阳性参与者中有 32 名（74.4%）至少有一次阳性。疼痛对病毒脱落的阳性预测值较差。
HSV 2 感染在年轻成年女性中非常普遍，但生殖器疱疹的症状并不常见。在大多数抗体阳性者中可以检测到 HSV 2 DNA 的脱落。需要采取早期干预策略来控制 HSV 2 感染。
Zotero 插件