肿瘤自然史中事件的稳定性。
The stability of events in the natural history of neoplasia.
作者信息
Pitot H C
出版信息
Am J Pathol. 1977 Dec;89(3):703-16.
Previous studies on the natural history of neoplasia, utilizing mouse skin as a model, have demonstrated that the process of epidermal carcinogenesis may be separated into at least two different phases. The first of these, termed "initiation," is essentially irreversible; the second phase, that of promotion, may be modulated or reversed by a variety of environmental conditions. More recently, similar stages have been demonstrated for other organ systems during carcinogenesis, in particular that of murine liver. At the same time, investigations of a variety of systems including those in plants, amphibians, and, most recently, in mammals have demonstrated that the initiation process of neoplasia may not be as irreversible as previously considered, but in several of these systems, including those in plants and in the mouse teratoma, the neoplastic process appears to be reversible from its initial stages under appropriate conditions. A proposed scheme is presented which takes into account the reversibility of the process of initiation in the natural history of neoplasia.
以往利用小鼠皮肤作为模型对肿瘤发生自然史的研究表明，表皮癌发生过程可至少分为两个不同阶段。其中第一个阶段，称为“启动”，基本上是不可逆的；第二个阶段，即促进阶段，可被多种环境条件调节或逆转。最近，在致癌过程中，其他器官系统，特别是鼠肝，也证实了类似阶段。与此同时，对包括植物、两栖动物以及最近的哺乳动物在内的各种系统的研究表明，肿瘤发生的启动过程可能不像以前认为的那样不可逆，但在其中一些系统中，包括植物和小鼠畸胎瘤中的系统，在适当条件下，肿瘤过程似乎从其初始阶段就可以逆转。本文提出了一个方案，该方案考虑了肿瘤发生自然史中启动过程的可逆性。
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