Friend C, Scher W, Holland J G, Sato T
Proc Natl Acad Sci U S A. 1971 Feb;68(2):378-82. doi: 10.1073/pnas.68.2.378.
Cells of a cloned line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by dimethyl sulfoxide at concentrations that did not inhibit growth. A rise in the number of benzidine-positive normoblasts was accompanied by increased synthesis of heme and hemoglobin and a decrease in the malignancy of the cells. This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their maturation.
在不抑制生长的浓度下，用二甲基亚砜刺激鼠病毒诱导的红白血病克隆系细胞，使其沿红系途径分化。联苯胺阳性的成红细胞数量增加，同时血红素和血红蛋白的合成增加，细胞恶性程度降低。二甲基亚砜的这种作用是可逆的，可能代表白血病细胞的去抑制，使其能够成熟。
