Barbason H, Smoliar V, Fridman-Manduzio A, Betz E H
Br J Cancer. 1979 Aug;40(2):260-7. doi: 10.1038/bjc.1979.174.
Diethylnitrosamine (DENA) at 10 mg/kg was fed to adult rats either continuously or for periods ranging from 1 to 10 weeks. Survival correlated inversely with the duration of carcinogen feeding. Less than 4 weeks of DENA feeding produced only preneoplastic foci that persisted indefinitely; 4 weeks were found to be necessary for the transformation of preneoplastic lesions into liver cancers; after 6 weeks, the incidence of hepatomas was 100%. The process of liver cancerization appeared to be identical whether DENA was fed for 8 weeks or continuously up to the time of death. These results are discussed in the light of the evolution of the homoeostatic control of liver-cell division during DENA feeding, in order to distinguish the different successive roles played by the carcinogen.
将10毫克/千克的二乙基亚硝胺（DENA）持续或在1至10周的时间段内喂给成年大鼠。存活率与致癌物喂养的持续时间呈负相关。少于4周的DENA喂养仅产生可无限期持续的癌前病灶；发现4周是癌前病变转化为肝癌所必需的；6周后，肝癌的发生率为100%。无论DENA是喂养8周还是持续到死亡时，肝癌形成过程似乎都是相同的。根据DENA喂养期间肝细胞分裂稳态控制的演变来讨论这些结果，以便区分致癌物所起的不同连续作用。
