生殖因素与胆道癌和胆道结石风险：中国上海基于人群的研究。
Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China.
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA.
出版信息
Br J Cancer. 2010 Mar 30;102(7):1185-9. doi: 10.1038/sj.bjc.6605597. Epub 2010 Mar 9.
Abstract
BACKGROUND
Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear.
METHODS
We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai.
RESULTS
The effects of parity (odds ratios, OR(> or =3 vs 1 child)=2.0, 95% confidence interval (CI) 0.7-5.1), younger age at first birth (OR(per 1-year decrease)=1.2, 95% CI 0.99-1.6), and older age at menarche (OR(per 1-year increase)=1.4, 95% CI 1.1-1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant.
CONCLUSION
Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.
摘要
背景
孕次与胆囊癌和胆囊结石有关，但其他生殖因素的影响尚不清楚。
方法
我们在上海进行了一项基于人群的研究，纳入了 361 例新发胆道癌病例、647 例胆石症病例和 586 名健康女性。
结果
孕次（≥3 次产 vs 1 次产的比值比（OR）=2.0，95%置信区间（CI）为 0.7-5.1）、初次生育年龄较小（每减少 1 岁 OR=1.2，95%CI 为 0.99-1.6）和初潮年龄较大（每增加 1 岁 OR=1.4，95%CI 为 1.1-1.8）与胆囊癌风险的相关性在结石女性中更为显著，但交互作用无统计学意义。
结论
我们的研究结果支持高孕次、初次生育年龄较小和初潮年龄较大与胆囊癌的发生相关，尤其是在患有胆石症的女性中。
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