Department of Cardiovascular Surgery, Musashino Red Cross Hospital, Musashino, Tokyo 180-8610, Japan.
J Infect Chemother. 2010 Aug;16(4):260-5. doi: 10.1007/s10156-010-0046-8. Epub 2010 Mar 10.
The relationship between infective endocarditis (IE) and vertebral osteomyelitis (VO) is uncertain. This study investigates the incidence of VO in patients with IE and the outcome of IE-associated VO. Among 58 patients with IE at Musashino Red Cross Hospital from January 2002 to July 2009, 11 patients (19.0%) had VO. Back pain was reported in all cases with VO. Because the antibiotics treatment for VO should continue for 6-8 weeks, hospital stay was significantly longer for patients with VO (75.8 +/- 41.0 days) compared to patients without VO (42.6 +/- 30.4 days; P = 0.0035). Although 6 hospital deaths (15.8%) occurred among the patients without VO, there were no hospital deaths among patients with VO. The 30- and 80-month survival was not significantly different between the patients with VO and without VO (30-month: 88.9% vs 81.7%, 80-month: 88.9% vs 74.3%, respectively). When specifically sought, the incidence of VO is high in patients with IE. VO does not appear to worsen the prognosis of IE, although the need for long hospital stays seems to be more frequent.
感染性心内膜炎（IE）与脊椎骨髓炎（VO）之间的关系尚不确定。本研究旨在调查 IE 患者中 VO 的发生率以及 IE 相关 VO 的转归。2002 年 1 月至 2009 年 7 月，在武藏野红十字医院的 58 例 IE 患者中，11 例（19.0%）患有 VO。所有 VO 患者均有背痛。由于 VO 的抗生素治疗应持续 6-8 周，因此患有 VO 的患者的住院时间明显长于无 VO 的患者（75.8 +/- 41.0 天 vs 42.6 +/- 30.4 天；P = 0.0035）。尽管无 VO 的患者中有 6 例（15.8%）院内死亡，但 VO 患者无院内死亡。VO 患者和无 VO 患者的 30 个月和 80 个月生存率无显著差异（30 个月：88.9% vs 81.7%，80 个月：88.9% vs 74.3%）。如果专门寻找，IE 患者的 VO 发生率较高。尽管需要长时间住院治疗，但 VO 似乎并未使 IE 的预后恶化。
