Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77230-1402, USA.
Lymphology. 2009 Dec;42(4):161-75.
We sought to define the incidence, risk factors, symptoms, and quality of life (QOL) outcomes associated with various degrees of postoperative limb volume change (LVC). A prospective cohort study was performed obtaining serial limb volume measurements using a perometer on 269 women undergoing surgery for breast cancer. Four groups were created based on maximum LVC: none < 5.0%, mild 5.0-9.9%, moderate 10.0-14.9%, and severe 15.0%. Symptoms and QOL were assessed. 81 (30.1%), 70 (26.0%), and 14 (5.2%) women developed mild, moderate, and severe LVC, respectively. Increases in body mass index (p < 0.001) and post-operative complications (p = 0.002) were associated with increasing LVC. Lower QOL scores were associated with a moderate LVC (OR = 3.72, 95% CI, 1.29-10.73, p = 0.015) and postoperative infections (OR = 5.04, 95% CI, 1.73-14.70, p = 0.003). LVC at 5.0% occurs in up to 61.3% of breast cancer survivors and is associated with a significant increase in symptoms and a change in reported quality of life.
我们旨在定义术后肢体体积变化（LVC）不同程度相关的发病率、风险因素、症状和生活质量（QOL）结局。对 269 名接受乳腺癌手术的女性进行了一项前瞻性队列研究，使用周径计连续测量肢体体积。根据最大 LVC 将患者分为 4 组：无变化＜5.0%、轻度 5.0-9.9%、中度 10.0-14.9%和重度 15.0%。评估了症状和 QOL。分别有 81 名（30.1%）、70 名（26.0%）和 14 名（5.2%）患者出现轻度、中度和重度 LVC。体重指数（BMI）增加（p＜0.001）和术后并发症（p=0.002）与 LVC 的增加相关。中度 LVC 与较低的 QOL 评分相关（OR=3.72，95%CI，1.29-10.73，p=0.015）和术后感染（OR=5.04，95%CI，1.73-14.70，p=0.003）。5.0%的 LVC 发生在多达 61.3%的乳腺癌幸存者中，与症状显著增加和报告的生活质量变化相关。
