Nacey J N, Delahunt B
Department of Surgery, Wellington School of Medicine, New Zealand.
Br J Urol. 1991 Mar;67(3):314-6. doi: 10.1111/j.1464-410x.1991.tb15143.x.
The hydrogel-coated urinary catheter is a novel formulation in which the coating hydrogel polymer is claimed to reduce the level of cytotoxicity frequently associated with the use of latex catheters. This study was undertaken to measure cytotoxicity using in vivo techniques. Twelve first generation and 5 second generation hydrogel-coated latex catheters were evaluated in vivo using canine urethras. The results showed all catheters to cause minimal inflammatory changes of the urethral mucosa (toxicity score 0-1.2/6).
水凝胶涂层导尿管是一种新型制剂，据称其涂层水凝胶聚合物可降低与使用乳胶导尿管相关的细胞毒性水平。本研究旨在采用体内技术测量细胞毒性。使用犬尿道对12根第一代和5根第二代水凝胶涂层乳胶导尿管进行了体内评估。结果显示，所有导尿管引起的尿道黏膜炎症变化均最小（毒性评分0 - 1.2/6）。
