Gabriel M M, Mayo M S, May L L, Simmons R B, Ahearn D G
Biology Department, Georgia State University, Atlanta 30302-4010, USA.
Curr Microbiol. 1996 Jul;33(1):1-5. doi: 10.1007/s002849900064.
Bacteria commonly associated with nosocomial urinary tract infections were examined in vitro for their relative adherence to latex, 100% silicone-, hydrogel-coated latex-, and hydrogel/silver-coated latex urinary catheters. Degrees of adherence within 2 h were determined with cells radiolabeled with leucine. Adherence was greatest and equivalent on silicone and latex catheters. Adherence of four strains of Escherichia coli to the hydrogel/silver-coated catheter was decreased by 50% to 99% in comparison with the other catheters. Repeat testing with strains of E. coli and Pseudomonas aeruginosa with over 50 catheters demonstrated a consistency in the inhibition. The hydrophilic coating of the catheter appeared to be primary in the decreased adherence phenomenon followed by a secondary biocidal effect of the silver ion.
对通常与医院获得性尿路感染相关的细菌进行了体外研究，以检测它们对乳胶、100%硅胶、水凝胶涂层乳胶和水凝胶/银涂层乳胶导尿管的相对黏附性。使用用亮氨酸进行放射性标记的细胞来测定2小时内的黏附程度。在硅胶导尿管和乳胶导尿管上的黏附性最强且相当。与其他导尿管相比，四株大肠杆菌对水凝胶/银涂层导尿管的黏附性降低了50%至99%。用50多个导尿管对大肠杆菌和铜绿假单胞菌菌株进行的重复测试表明这种抑制作用具有一致性。导尿管的亲水性涂层似乎是导致黏附性降低现象的主要因素，其次是银离子的二次杀菌作用。
