Morgan Maria A, Cragan Janet D, Goldenberg Robert L, Rasmussen Sonja A, Schulkin Jay
American College of Obstetricians and Gynecologists, Washington, DC 20024, USA.
J Matern Fetal Neonatal Med. 2010 Oct;23(10):1143-50. doi: 10.3109/14767051003653252.
To assess opinions, knowledge, and informational resources of obstetrician-gynaecologists regarding the safety of medication use during pregnancy.
A questionnaire was mailed to 770 members of the American College of Obstetricians and Gynecologists who participate in the Collaborative Ambulatory Research Network.
The response rate was 58%. Of these, 305 respondents provide both routine gynecologic and obstetric care and are the focus of the study. There was wide variation in obstetrician-gynaecologists' assessments of the safety for the foetus of medications ranging from aspirin to valproic acid. The Physicians' Desk Reference was most frequently (75%) cited as a source of information about medication safety. Forty-two percent of obstetrician-gynaecologists selected lack of sufficient information on medications as the greatest barrier to counselling pregnant women about their use, while only 4% selected lack of access to information as the greatest barrier. Most (79%) obstetrician-gynaecologists indicated they would be willing to participate in pregnancy exposure registries, but far fewer (24%) reported having done so.
These results emphasise the need for safety information about the effects of medication use during pregnancy and suggest that pregnancy exposure registries are underutilised.
评估妇产科医生对于孕期用药安全性的观点、知识及信息来源。
向参与协作门诊研究网络的770名美国妇产科医师学会成员邮寄了一份调查问卷。
回复率为58%。其中，305名受访者同时提供常规妇科和产科护理，是本研究的重点对象。妇产科医生对从阿司匹林到丙戊酸等药物对胎儿安全性的评估存在很大差异。《医师案头参考手册》被最频繁地（75%）引为药物安全性信息来源。42%的妇产科医生认为缺乏足够的药物信息是为孕妇提供用药咨询的最大障碍，而只有4%的人选择信息获取不便作为最大障碍。大多数（79%）妇产科医生表示愿意参与孕期暴露登记，但实际报告参与过的人要少得多（24%）。
这些结果强调了孕期用药影响的安全信息的必要性，并表明孕期暴露登记的利用不足。
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