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脾脏小结节状 T 细胞/组织细胞丰富的 B 细胞淋巴瘤伴小淋巴细胞淋巴瘤:里希特转化。

Micronodular T-cell/histiocyte-rich B-cell lymphoma of the spleen in a case of small lymphocytic lymphoma: a Richter's transformation.

机构信息

Department of Pathology, Marmara University School of Medicine, and Sisli Etfal Education and Research Hospital, Istanbul, Turkey.

出版信息

Ups J Med Sci. 2010 Aug;115(3):217-9. doi: 10.3109/03009731003686920.

DOI:10.3109/03009731003686920
PMID:20218944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2939524/
Abstract

Abstract A case of micronodular T-cell/histiocyte-rich B-cell lymphoma of the spleen who had a prior diagnosis of small lymphocytic lymphoma is presented. Micronodular T-cell/histiocyte-rich B-cell lymphoma of the spleen was first described in 2003, and very few cases have been reported since then. This is the first reported case supervening in a patient with pre-existing chronic lymphocytic lymphoma. We review its clinical, pathologic, and immunohistochemical features and the difficulties we encountered during diagnosis.

摘要

摘要 本文报告了一例脾脏微结节性 T 细胞/组织细胞丰富的 B 细胞淋巴瘤病例,该患者先前被诊断为小淋巴细胞淋巴瘤。脾脏微结节性 T 细胞/组织细胞丰富的 B 细胞淋巴瘤于 2003 年首次描述,此后仅报道了少数病例。这是首例在患有慢性淋巴细胞性淋巴瘤的患者中并发的病例。我们回顾了其临床、病理和免疫组织化学特征以及在诊断过程中遇到的困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27de/2939524/2eaf32f99059/UPS-0300-9734-115-217-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27de/2939524/e92aa469f2a5/UPS-0300-9734-115-217-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27de/2939524/6cb16e5cbe40/UPS-0300-9734-115-217-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27de/2939524/8dd7b1dcd463/UPS-0300-9734-115-217-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27de/2939524/2eaf32f99059/UPS-0300-9734-115-217-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27de/2939524/e92aa469f2a5/UPS-0300-9734-115-217-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27de/2939524/6cb16e5cbe40/UPS-0300-9734-115-217-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27de/2939524/8dd7b1dcd463/UPS-0300-9734-115-217-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27de/2939524/2eaf32f99059/UPS-0300-9734-115-217-g004.jpg

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本文引用的文献

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Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma.脾脏微结节性富含T细胞/组织细胞的大B细胞淋巴瘤。
Ann Diagn Pathol. 2008 Aug;12(4):290-292. doi: 10.1016/j.anndiagpath.2006.12.006. Epub 2007 Sep 14.
2
Splenic marginal zone lymphoma with micronodular T-cell rich B-cell lymphoma.伴有微结节性富含T细胞的B细胞淋巴瘤的脾边缘区淋巴瘤
Am J Surg Pathol. 2006 Jan;30(1):128-32. doi: 10.1097/01.pas.0000174268.22331.8d.
3
T-cell-rich B-cell lymphoma presenting in the spleen: a clinicopathologic analysis of 3 cases.脾脏富于T细胞的B细胞淋巴瘤:3例临床病理分析
Int J Surg Pathol. 2004 Jan;12(1):31-7. doi: 10.1177/106689690401200105.
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[RICHTER'S SYNDROME].[里氏综合征]
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Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis.脾脏微结节性富含T细胞/组织细胞的大B细胞淋巴瘤:组织学、免疫表型及鉴别诊断
Am J Surg Pathol. 2003 Jul;27(7):903-11. doi: 10.1097/00000478-200307000-00005.
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Large B-cell lymphoma presenting in the spleen: identification of different clinicopathologic conditions.脾脏原发性大B细胞淋巴瘤:不同临床病理情况的鉴定
Am J Surg Pathol. 2003 Jul;27(7):895-902. doi: 10.1097/00000478-200307000-00004.
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Progression to large B-cell lymphoma in splenic marginal zone lymphoma: a description of a series of 12 cases.脾边缘区淋巴瘤进展为大B细胞淋巴瘤:12例病例系列描述
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Malignant lymphoma supervening in chronic lymphocytic leukemia and related disorders. Richter's syndrome: a study of 25 cases.慢性淋巴细胞白血病及相关疾病并发的恶性淋巴瘤。里氏综合征:25例研究。
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