Department of Medical Microbiology and Immunology, University of Pecs, Medical School, Hungary.
Am J Reprod Immunol. 2012 Jan;67(1):9-16. doi: 10.1111/j.1600-0897.2011.01029.x. Epub 2011 Jun 20.
PROBLEM The aim of this study was to investigate the phenotype and commitment of decidual haematopoietic progenitor cells (HPCs) in healthy pregnant women and in women with early miscarriage. METHOD OF STUDY Peripheral blood and decidual tissue from healthy and pathological pregnant women were examined for HPCs and lymphoid progenitors using flow cytometric analysis. RESULTS Compared with peripheral blood, we found a significant increase in decidual HPCs in both healthy pregnant women and women with spontaneous abortion. T/NK, natural killer (NK), gamma-delta and NKT cell progenitors were identified in all peripheral blood and decidual samples. In pathologic pregnant women, the ratios of decidual T/NK and NK cell progenitors were significantly increased compared with healthy pregnant controls. CONCLUSION We demonstrated decidual cells with haematopoietic progenitor cell phenotype in human decidua. Increased levels of NK progenitors in the decidua of women with early spontaneous abortion suggest a dysregulation of this pathway that may contribute to pregnancy failure.
问题 本研究旨在探讨健康孕妇和早期自然流产孕妇蜕膜造血祖细胞（HPC）的表型和定向分化能力。 研究方法 采用流式细胞术分析健康妊娠和病理性妊娠孕妇外周血和蜕膜组织中的 HPC 和淋巴祖细胞。 结果 与外周血相比，我们发现健康妊娠妇女和自然流产妇女的蜕膜 HPC 均显著增加。所有外周血和蜕膜样本中均鉴定出 T/NK、自然杀伤（NK）、γ-δ和 NKT 细胞祖细胞。与健康妊娠对照组相比，病理性妊娠孕妇的蜕膜 T/NK 和 NK 细胞祖细胞比例明显升高。 结论 我们在人蜕膜中证实了具有造血祖细胞表型的蜕膜细胞。早期自然流产妇女蜕膜中 NK 祖细胞水平升高提示该途径失调，可能导致妊娠失败。
