Functional Nanomaterials Laboratory and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), Zhongguancun Beiyitiao 2, Haidianqu, Beijing 100190, China.
J Colloid Interface Sci. 2010 May 15;345(2):269-77. doi: 10.1016/j.jcis.2010.02.012. Epub 2010 Feb 11.
In this work, in situ encapsulation of ibuprofen (IBU) was explored preliminarily using the emulsion sol-gel method. IBU-containing porous silica nanospheres (300-400 nm) of varied morphologies were fabricated simply by tailoring the amount of IBU in the starting solution. In the reaction system, IBU exists in the form of IBU(-) under basic conditions, which has strong electrostatic interaction with CTA(+), and thus could be regarded as cosurfactant to regulate the morphology and structure of silica nanospheres. Such morphology can be maintained even after calcination or IBU release in phosphate-buffered saline. The current results may shed light on the design and construction of new functional nanoarchitectures, which may be useful for drug delivery, separation, adsorption, catalysis, etc.
在这项工作中，初步探索了使用乳液溶胶-凝胶法进行布洛芬（IBU）的原位封装。通过调整起始溶液中 IBU 的用量，可以简单地制备出具有不同形态的含 IBU 的多孔硅纳米球（300-400nm）。在反应体系中，IBU 在碱性条件下以 IBU(-)的形式存在，与 CTA(+)具有很强的静电相互作用，因此可以作为助表面活性剂来调节硅纳米球的形态和结构。这种形态即使在煅烧或在磷酸盐缓冲盐中释放 IBU 后也能保持。目前的结果可能为设计和构建新的功能纳米结构提供启示，这对于药物输送、分离、吸附、催化等可能是有用的。
