Wen Li-Xiong, Ding Hao-Min, Wang Jie-Xin, Chen Jian-Feng
Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, PR China.
J Nanosci Nanotechnol. 2006 Sep-Oct;6(9-10):3139-44. doi: 10.1166/jnn.2006.410.
With two different methods, ibuprofen was entrapped into porous hollow silica nanoparticles (PHSNs) carriers, which were synthesized through a sol-gel route by using CaCO3 nanoparticles as the inorganic templates. By employing pressured CO2 as the loading medium, the amount of ibuprofen that was pressed into the carriers was approximately 52% higher than that by simply soaking. The drug release behaviors of the ibuprofen-loaded PHSNs were investigated in a simulated intestine juice and an artificial gastric fluid, respectively, and it demonstrated a sustained release pattern in all cases and the sample prepared under high pressure had a lower release rate in both fluids and thus owned a greater sustained drug release capacity. In the acidic artificial gastric fluid, no silica was degraded and only 16% of the loaded ibuprofen was released from the matrix in 300 min. However, much more silica was degraded in the simulated intestine juice in a shorter time and almost all the loaded ibuprofen was dissolved into the solution eventually, resulting in a quicker and complete ibuprofen release. Therefore, the PHSNs can be utilized for applications of controlled drug delivery to small intestine.
采用两种不同方法，将布洛芬包封于多孔中空二氧化硅纳米颗粒（PHSNs）载体中，该载体通过以碳酸钙纳米颗粒为无机模板，经溶胶 - 凝胶法合成。以加压二氧化碳作为负载介质，压入载体中的布洛芬量比单纯浸泡法高出约52%。分别在模拟肠液和人工胃液中研究了负载布洛芬的PHSNs的药物释放行为，结果表明在所有情况下均呈现缓释模式，高压下制备的样品在两种液体中的释放速率均较低，因此具有更大的药物缓释能力。在酸性人工胃液中，二氧化硅未降解，300分钟内仅16%负载的布洛芬从基质中释放。然而，在模拟肠液中，二氧化硅在更短时间内降解更多，最终几乎所有负载的布洛芬都溶解到溶液中，导致布洛芬更快且完全释放。因此，PHSNs可用于小肠控释给药应用。
