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红色微藻细胞壁多糖:生物技术方面。

Red microalgal cell-wall polysaccharides: biotechnological aspects.

机构信息

Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

出版信息

Curr Opin Biotechnol. 2010 Jun;21(3):358-64. doi: 10.1016/j.copbio.2010.02.008. Epub 2010 Mar 10.

Abstract

The area of sugars and glycosylation is not as well developed as other fields in cell biology owing to biotechnological constraints. However, the biotechnological potential of sugars, including polysaccharides, is the driving force pushing research efforts to meet the challenge. Algae produce cell-wall sulfated polysaccharides, with those of the red unicells, which dissolve into the medium, having unique characteristics-structure, composition, fluid dynamics, and extreme stability. These characteristics, combined with polysaccharide bioactivities, offer a vast range of potential applications. Research has thus been directed toward an in-depth understanding of the molecular structure, biosynthesis, and characteristics of the red microalgal sulfated polysaccharides and to the development of molecular-genetic tools, aiming at large-scale production for applications that can benefit humanity.

摘要

由于生物技术方面的限制,糖和糖基化领域的发展不如细胞生物学的其他领域完善。然而,包括多糖在内的糖的生物技术潜力是推动研究工作以迎接挑战的动力。藻类产生细胞壁硫酸化多糖,其中红色单细胞的多糖会溶解到培养基中,具有独特的特性——结构、组成、流体动力学和极端稳定性。这些特性与多糖的生物活性相结合,提供了广泛的潜在应用。因此,研究的重点是深入了解红色微藻硫酸化多糖的分子结构、生物合成和特性,并开发分子遗传工具,旨在大规模生产造福人类的应用产品。

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