犬非典型库欣综合征：支持与反对的观点

Atypical Cushing's syndrome in dogs: arguments for and against.

作者信息

Behrend Ellen N, Kennis Robert

机构信息

Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.

出版信息

Vet Clin North Am Small Anim Pract. 2010 Mar;40(2):285-96. doi: 10.1016/j.cvsm.2009.11.002.

DOI:10.1016/j.cvsm.2009.11.002

PMID:20219489

Abstract

In the past 5 to 10 years, much interest has arisen in the syndrome of occult hyperadrenocorticism. Patients with occult hyperadrenocorticism purportedly have many clinical signs and routine laboratory abnormalities suggestive of the presence of typical hyperadrenocorticism, or Cushing's syndrome (ie, hypercortisolism either due to a pituitary or adrenal tumor). However, the standard diagnostic tests-corticotropin (ACTH) stimulation and low-dose dexamethasone suppression tests-are normal. A theory has arisen that the clinical signs of occult hyperadrenocorticism are due to excess adrenal secretion of sex hormones rather than cortisol. The authors believe that the role of sex hormones has not been proven. The article reviews the evidence both for and against the importance of sex hormones in creating occult hyperadrenocorticism.

摘要

在过去5到10年里，隐匿性肾上腺皮质功能亢进综合征引起了人们的广泛关注。据称，隐匿性肾上腺皮质功能亢进患者有许多临床体征和常规实验室异常，提示存在典型的肾上腺皮质功能亢进，即库欣综合征（即由于垂体或肾上腺肿瘤导致的高皮质醇血症）。然而，标准诊断测试——促肾上腺皮质激素（ACTH）刺激试验和小剂量地塞米松抑制试验——结果均正常。有一种理论认为，隐匿性肾上腺皮质功能亢进的临床体征是由于肾上腺过度分泌性激素而非皮质醇所致。作者认为，性激素的作用尚未得到证实。本文回顾了支持和反对性激素在隐匿性肾上腺皮质功能亢进发生中起重要作用的证据。