Greco Deborah S
Nestle Purina Petcare, One Checkerboard Square, St. Louis, MO 63164, USA.
Clin Tech Small Anim Pract. 2007 Feb;22(1):12-7. doi: 10.1053/j.ctsap.2007.02.002.
Diagnosis of sex steroid excess or hyperadrenocorticism in dogs may be challenging. Unlike Cushing's disease, sex steroid excess may have a multitude of manifestations that differ from standard hyperadrenocorticism. In particular, the clinical scenario of a dog with sex steroid imbalance involves one of three systems: dermatologic, reproductive, or hepatic. The history of a dog with hyperadrenocorticism manifesting as sex steroid imbalance often lacks the classical clinical signs of polydipsia and polyuria. Dogs with sex steroid imbalance will often be of specific breeds such as miniature poodles and exhibit trunkal hair loss as the only sign. There is often involvement of the reproductive system, manifested as the growth of perianal adenomas in neutered male or female dogs. The most common laboratory findings consist of elevations in serum alkaline phosphatase and serum alanine transferase. The following article reviews the etiology, common signalment, clinical signs, and laboratory findings associated with atypical hyperadrenocorticism caused by sex steroid imbalance and then explores the medical, surgical, and radiation treatment options.
诊断犬类的性类固醇过量或肾上腺皮质功能亢进可能具有挑战性。与库欣病不同，性类固醇过量可能有多种表现，与标准的肾上腺皮质功能亢进有所不同。特别是，患有性类固醇失衡的犬的临床情况涉及三个系统之一：皮肤、生殖或肝脏。表现为性类固醇失衡的肾上腺皮质功能亢进犬的病史通常缺乏多饮和多尿的典型临床症状。患有性类固醇失衡的犬通常为特定品种，如迷你贵宾犬，且仅表现为躯干脱毛。生殖系统常受累，表现为绝育的雄性或雌性犬肛周腺瘤的生长。最常见的实验室检查结果包括血清碱性磷酸酶和血清丙氨酸转氨酶升高。以下文章回顾了与性类固醇失衡引起的非典型肾上腺皮质功能亢进相关的病因、常见特征、临床症状和实验室检查结果，然后探讨了药物、手术和放射治疗方案。
