蛋白质乙酰化在突触可塑性和记忆中的作用。

Protein acetylation in synaptic plasticity and memory.

机构信息

National Brain Research Centre, Cellular and Molecular Neuroscience, Manesar, Haryana, India.

出版信息

Neurosci Biobehav Rev. 2010 Jul;34(8):1234-40. doi: 10.1016/j.neubiorev.2010.02.009. Epub 2010 Feb 26.

DOI:10.1016/j.neubiorev.2010.02.009

PMID:20219532

Abstract

Posttranslational modifications of proteins regulate various processes in the cells. The seminal role of phosphorylation in synaptic plasticity and memory has been established using several different model systems. Recently, an important role for another posttranslational modification, acetylation, particularly of histones, has emerged in these processes. This review focuses on the role of activity-dependent protein acetylation in synaptic plasticity and memory.

摘要

蛋白质的翻译后修饰调节细胞中的各种过程。使用几种不同的模型系统已经确立了磷酸化在突触可塑性和记忆中的重要作用。最近，另一种翻译后修饰，即乙酰化，特别是组蛋白的乙酰化，在这些过程中也发挥了重要作用。本文综述了活性依赖性蛋白质乙酰化在突触可塑性和记忆中的作用。