Batista Aline Carvalho, Costa Nádia Lago, Oton-Leite Angélica Ferreira, Mendonça Elismauro Francisco, Alencar Rita de Cássia Gonçalves, Silva Tarcília Aparecida
Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Mar;109(3):e74-9. doi: 10.1016/j.tripleo.2009.10.034.
This study was undertaken to gain insight into the distinctive features of squamous cell carcinoma of the lip (LSCC) and oral cavity (OCSCC).
A total of 37 cases of LSCC and 54 of OCSCC were compared regarding clinical and microscopic findings.
Predominance of head and neck TNM stages (HNTNM) T1-T2 in LSCC and T3-T4 in OCSCC was observed. A significant percentage (33.3%) of patients with OCSCC at HNTNM T1-T2 presented cervical lymph node metastasis and 18.75% died, whereas lymph node metastasis was absent and no patient died with LSCC at HNTNM T1-T2. LSCC demonstrated a higher number of cases with intense peritumoral inflammatory infiltrate compared with OCSCC. The analysis of the proliferative index demonstrated a significantly higher percentage of PCNA+ and Ki-67+ cells in OCSCC compared with LSCC.
Our results suggest that OCSCC and LSCC demonstrate distinct clinical and microscopic characteristics that reflect different biologic behavior and prognosis.
开展本研究以深入了解唇鳞状细胞癌（LSCC）和口腔鳞状细胞癌（OCSCC）的独特特征。
对37例LSCC和54例OCSCC的临床及显微镜检查结果进行比较。
观察到LSCC中头颈部TNM分期（HNTNM）以T1 - T2为主，而OCSCC中以T3 - T4为主。在HNTNM T1 - T2期的OCSCC患者中，有相当比例（33.3%）出现颈部淋巴结转移，18.75%的患者死亡；而在HNTNM T1 - T2期的LSCC患者中未出现淋巴结转移，也无患者死亡。与OCSCC相比，LSCC中肿瘤周围有强烈炎性浸润的病例数更多。增殖指数分析显示，与LSCC相比，OCSCC中PCNA +和Ki - 67 +细胞的比例显著更高。
我们的结果表明，OCSCC和LSCC表现出不同的临床和显微镜特征，反映了不同的生物学行为和预后。
