Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 537061, USA.
J Virol. 2010 May;84(10):5443-7. doi: 10.1128/JVI.02452-09. Epub 2010 Mar 10.
Human and simian immunodeficiency viruses (HIV and SIV) downregulate major histocompatibility complex class I (MHC-I) molecules from the surface of infected cells. Although this activity is conserved across viral isolates, its importance in AIDS pathogenesis is not clear. We therefore developed an assay to detect the level of MHC-I expression of SIV-infected cells directly ex vivo. Here we show that the extent of MHC-I downregulation is greatest in SIVmac239-infected macaques that never effectively control virus replication. Our results suggest that a high level of MHC-I downregulation is a hallmark of fast disease progression in SIV infection.
人类和猿猴免疫缺陷病毒（HIV 和 SIV）会下调受感染细胞表面的主要组织相容性复合体 I 类（MHC-I）分子。尽管这种活性在病毒分离株中是保守的，但它在艾滋病发病机制中的重要性尚不清楚。因此，我们开发了一种检测 SIV 感染细胞 MHC-I 表达水平的体外检测方法。在这里，我们发现，从未有效控制病毒复制的 SIVmac239 感染的猕猴中，MHC-I 的下调程度最大。我们的结果表明，高水平的 MHC-I 下调是 SIV 感染中快速疾病进展的标志。
