胃癌中18F-氟脱氧葡萄糖摄取的变化与葡萄糖转运蛋白1（GLUT-1）的不同表达水平相关。

Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression.

作者信息

Alakus Hakan, Batur Mert, Schmidt Matthias, Drebber Uta, Baldus Stephan E, Vallböhmer Daniel, Prenzel Klaus L, Metzger Ralf, Bollschweiler Elfriede, Hölscher Arnulf H, Mönig Stefan P

机构信息

Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany.

出版信息

Nucl Med Commun. 2010 Jun;31(6):532-8. doi: 10.1097/MNM.0b013e32833823ac.

DOI:10.1097/MNM.0b013e32833823ac

PMID:20220543

Abstract

OBJECTIVES

Detection rates of gastric cancer in F-fluorodeoxyglucose (FDG)-PET depend on the histopathological characteristics of the primary tumor. To clarify this observation, FDG uptake in gastric carcinoma was analyzed by focusing on histopathology and on the expression of the glucose transporter (GLUT-1) in the primary tumor.

METHODS

Thirty-five patients with the diagnosis of gastric cancer underwent FDG-PET with visual image analysis and measurement of maximum standardized uptake value (SUV(max)) before surgical treatment. Resected tumor samples were categorized according to Union internationale contre le cancer, WHO, and Laurén classification and tumor differentiation. GLUT-1 expression was graded semiquantitatively by immunohistochemistry. Statistical analysis was done for the correlation of histology, different classifications, and tumor grading with SUV(max) and GLUT-1 expression.

RESULTS

SUV(max) significantly correlated with histopathological classifications according to the WHO (P=0.009) and Laurén classification (P=0.034). Signet-ring cell carcinoma had a median SUV(max) of only 3.0 (range, 1.0-11.5). Median SUV(max) for papillary and tubular carcinoma was 7.8 (range, 1.8-14.4). In 21 (60%) cases, GLUT-1 expression in the primary tumor was positive. GLUT-1 expression correlated significantly with tumor differentiation (P=0.018) and the classification according to Laurén (P=0.023) and WHO (P<0.001). Thirteen (76%) of 17 signet-ring cell carcinoma cases did not show any GLUT-1 expression. SUV(max) in relation to GLUT-1 expression showed a significant correlation (P=0.002). For cases with detectable GLUT-1 expression the median SUV(max) was 6.9 (range, 2.3-14.1) versus a median of 3.1 (range, 1-8.8) for cases without GLUT-1 expression.

CONCLUSION

FDG uptake in gastric cancer depends on GLUT-1 expression. One major reason for low FDG uptake in signet-ring cell carcinoma is the low GLUT-1 expression in this histological subtype of gastric cancer.

摘要

目的

氟脱氧葡萄糖（FDG）-PET对胃癌的检测率取决于原发肿瘤的组织病理学特征。为阐明这一现象，通过关注原发肿瘤的组织病理学及葡萄糖转运蛋白（GLUT-1）的表达情况，对胃癌中的FDG摄取进行分析。

方法

35例确诊为胃癌的患者在手术治疗前行FDG-PET检查，并进行视觉图像分析及测量最大标准化摄取值（SUV(max)）。切除的肿瘤样本根据国际抗癌联盟、世界卫生组织及劳伦分类法进行分类，并评估肿瘤分化程度。通过免疫组织化学对GLUT-1表达进行半定量分级。对组织学、不同分类及肿瘤分级与SUV(max)及GLUT-1表达之间的相关性进行统计学分析。

结果

SUV(max)与世界卫生组织（P = 0.009）及劳伦分类法（P = 0.034）的组织病理学分类显著相关。印戒细胞癌的SUV(max)中位数仅为3.0（范围1.0 - 11.5）。乳头状和管状癌的SUV(max)中位数为7.8（范围1.8 - 14.4）。在21例（60%）病例中，原发肿瘤的GLUT-1表达呈阳性。GLUT-1表达与肿瘤分化程度（P = 0.018）、劳伦分类法（P = 0.023）及世界卫生组织分类法（P < 0.001）显著相关。17例印戒细胞癌病例中有13例（76%）未显示任何GLUT-1表达。SUV(max)与GLUT-1表达呈显著相关（P = 0.002）。对于可检测到GLUT-1表达的病例，SUV(max)中位数为6.9（范围2.3 - 14.1），而对于无GLUT-1表达的病例，中位数为3.1（范围1 - 8.8）。