Monaghan J C, Flemming C L, Stokes G S
Department of Clinical Pharmacology, Royal North Shore Hospital, St Leonards, N.S.W. Australia.
Clin Exp Hypertens A. 1991;13(1):53-63. doi: 10.3109/10641969109082614.
The effects of 17 alpha-ethinyl oestradiol in vitro upon erythrocyte Na(+)-K+ cotransport were investigated in nine normal males and in eight normal females during the mid-follicular phase of the menstrual cycle. At a concentration of 10(-1) mmol/l, Na(+)-K+ cotransport was almost completely inhibited. At concentrations of 10(-12) to 10(-2) mmol/l, a minor concentration-related effect was observed in males but not females. In the same concentration range, there was a significant difference in Na(+)-K+ cotransport between sexes. Thus, erythrocyte Na+K+ cotransport is lower in females than males, probably due to chronic exposure of their erythrocytes to endogenous oestrogen.
在月经周期的卵泡中期，对9名正常男性和8名正常女性体外研究了17α-乙炔雌二醇对红细胞钠钾协同转运的影响。在浓度为10⁻¹mmol/L时，钠钾协同转运几乎完全被抑制。在浓度为10⁻¹²至10⁻²mmol/L时，在男性中观察到与浓度相关的轻微影响，而在女性中未观察到。在相同浓度范围内，两性之间的钠钾协同转运存在显著差异。因此，女性红细胞的钠钾协同转运低于男性，这可能是由于其红细胞长期暴露于内源性雌激素所致。
