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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Morgan T, Barrett G, Zhang Y L, Alcorn D

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1991 Feb;18(2):123-6. doi: 10.1111/j.1440-1681.1991.tb01421.x.

The role of the macula densa in renin synthesis was studied using mice with one hydronephrotic kidney. 2. Renin synthesis was assessed by measurement of renal renin, renal mRNA for renin and plasma renin. 3. Sodium depletion stimulated mRNA and renal renin to a similar extent in the hydronephrotic and contralateral kidney. 4. Enalapril stimulated mRNA concentration in both kidneys but renal renin did not rise in the hydronephrotic kidney. 5. Propranolol did not alter the response to sodium depletion in either kidney. 6. The macula densa is not crucial for the stimulation of renin synthesis following sodium depletion. However, it may regulate renin production after mRNA synthesis, possibly by controlling the conversion of prorenin to renin.

利用一侧肾积水的小鼠研究致密斑在肾素合成中的作用。2. 通过测量肾肾素、肾素的肾mRNA和血浆肾素评估肾素合成。3. 钠缺失在肾积水肾脏和对侧肾脏中对mRNA和肾肾素的刺激程度相似。4. 依那普利刺激双侧肾脏中的mRNA浓度，但肾积水肾脏中的肾肾素未升高。5. 普萘洛尔未改变任一肾脏对钠缺失的反应。6. 致密斑对于钠缺失后肾素合成的刺激并非至关重要。然而，它可能在mRNA合成后调节肾素产生，可能是通过控制肾素原向肾素的转化。

Morgan T, Barrett G, Zhang Y L, Alcorn D

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1991 Feb;18(2):123-6. doi: 10.1111/j.1440-1681.1991.tb01421.x.

The role of the macula densa in renin synthesis was studied using mice with one hydronephrotic kidney. 2. Renin synthesis was assessed by measurement of renal renin, renal mRNA for renin and plasma renin. 3. Sodium depletion stimulated mRNA and renal renin to a similar extent in the hydronephrotic and contralateral kidney. 4. Enalapril stimulated mRNA concentration in both kidneys but renal renin did not rise in the hydronephrotic kidney. 5. Propranolol did not alter the response to sodium depletion in either kidney. 6. The macula densa is not crucial for the stimulation of renin synthesis following sodium depletion. However, it may regulate renin production after mRNA synthesis, possibly by controlling the conversion of prorenin to renin.

利用一侧肾积水的小鼠研究致密斑在肾素合成中的作用。2. 通过测量肾肾素、肾素的肾mRNA和血浆肾素评估肾素合成。3. 钠缺失在肾积水肾脏和对侧肾脏中对mRNA和肾肾素的刺激程度相似。4. 依那普利刺激双侧肾脏中的mRNA浓度，但肾积水肾脏中的肾肾素未升高。5. 普萘洛尔未改变任一肾脏对钠缺失的反应。6. 致密斑对于钠缺失后肾素合成的刺激并非至关重要。然而，它可能在mRNA合成后调节肾素产生，可能是通过控制肾素原向肾素的转化。