Lobodzińska M, Albin M
Arch Immunol Ther Exp (Warsz). 1980;28(2):323-8.
Inbred 129/Ao/Boy mice were infected with various doses of AO/PR8/HONI influenza virus. Replication of virus, synthesis of endogenous interferon and antibodies were measured. The infected mice were the source of alveolar and peritoneal cells which were used for the in vitro induction of interferon with Newcastle Disease virus (NDV). It has been found that the level of interferon detected in the tracheo-bronchial washings parallels the titer of virus in the lung. At the lethal doses of the virus interferon appeared earlier but its titer also declined faster than in mice infected with sublethal doses of influenza virus. The peritoneal and alveolar cells from the mice infected with the lethal doses of influenza virus produced less interferon after the induction with NDV than the cells from uninfected mice. In contrast, the alveolar cells from mice infected with sublethal doses of A/PR8 virus produced more interferon than the control cells.
将近交系129/Ao/Boy小鼠用不同剂量的AO/PR8/HONI流感病毒进行感染。检测病毒复制、内源性干扰素合成及抗体情况。感染小鼠是肺泡细胞和腹腔细胞的来源，这些细胞用于用新城疫病毒（NDV）进行体外干扰素诱导。已发现，在气管支气管灌洗液中检测到的干扰素水平与肺内病毒滴度平行。在病毒致死剂量下，干扰素出现得更早，但其滴度下降速度也比感染亚致死剂量流感病毒的小鼠更快。用致死剂量流感病毒感染的小鼠的腹腔细胞和肺泡细胞在用NDV诱导后产生的干扰素比未感染小鼠的细胞少。相比之下，用亚致死剂量A/PR8病毒感染的小鼠的肺泡细胞产生的干扰素比对照细胞多。
