Deuschl G, Michels R, Berardelli A, Schenck E, Inghilleri M, Lücking C H
Neurologische Klinik und Poliklinik, Universität Freiburg, Federal Republic of Germany.
Exp Brain Res. 1991;83(2):403-10. doi: 10.1007/BF00231165.
The interaction of transcranial electric and magnetic brain stimulation with electrically elicited short- and long latency reflexes (LLR) of hand and forearm flexor muscles has been investigated in normal subjects. In the first paradigm, the motor potential evoked in thenar muscles by transcranial stimulation was conditioned by median nerve stimulation at various conditioning-test intervals. At short intervals (electric: 5-12.5 ms, magnetic: 0-7.5 ms) facilitation occurred that corresponded to the H-reflex and at longer intervals (electric: 25-40 ms, magnetic: 22.5-35 ms) there was a facilitation corresponding to the LLR. Electric and magnetic stimulation resulted in a similar degree of facilitation. A second paradigm investigated the facilitation of the forearm flexor H-reflex by a cutaneo-muscular LLR elicited by radial superficial nerve stimulation and transcranial stimulation used separately or together. When electric and magnetic brain stimulation were compared, magnetic brain stimulation was followed by significant extrafacilitation but electric stimulation was not. This result favours an interaction between the afferent volley eliciting the LLR and transcranial magnetic stimulation most likely at supraspinal level.
在正常受试者中，研究了经颅电刺激和磁刺激与手部和前臂屈肌的电诱发短潜伏期和长潜伏期反射（LLR）之间的相互作用。在第一个范式中，经颅刺激在大鱼际肌中诱发的运动电位，在不同的条件刺激-测试间隔下，由正中神经刺激进行条件设定。在短间隔（电刺激：5 - 12.5毫秒，磁刺激：0 - 7.5毫秒）时出现与H反射相对应的易化，在较长间隔（电刺激：25 - 40毫秒，磁刺激：22.5 - 35毫秒）时出现与LLR相对应的易化。电刺激和磁刺激产生的易化程度相似。第二个范式研究了单独或联合使用桡浅神经刺激和经颅刺激诱发的皮肤-肌肉LLR对前臂屈肌H反射的易化作用。当比较电刺激和磁刺激时，磁刺激后出现显著的额外易化，但电刺激没有。这一结果支持在脊髓上水平，引发LLR的传入冲动与经颅磁刺激之间存在相互作用。
