Proaño A R, Medrano A, Garrido G, Mazza O
División de Urología, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina.
Actas Urol Esp. 2010 Jan;34(1):15-23.
The knowledge of the urinary effort incontinence (UEI) has increased, giving like result an ample range of different therapeutic options available. The middle urethra and external urethral sphincter are the focus in management of UEI. Stem cells therapy for the regenerative repair of the deficient sphincter has been the leading research of incontinence. Obtaining autologous myoblasts and fibroblasts of skeletal muscle-biopsies, cultivating them and transplanting them after its differentiation, into the external urethral sphincter it warns a new concept in the treatment of the incontinence. Instead of using heterologous materials such as synthetic mesh (slings) or bulking agents (collagen, silicone, etc); we now have the potential to restore function with the use of autologous stem cells.
人们对压力性尿失禁（UEI）的认识有所增加，结果产生了一系列不同的可用治疗选择。尿道中段和尿道外括约肌是压力性尿失禁管理的重点。用于再生修复功能不全括约肌的干细胞疗法一直是尿失禁研究的前沿领域。获取骨骼肌活检的自体成肌细胞和成纤维细胞，培养它们并在其分化后将其移植到尿道外括约肌中，这为尿失禁的治疗提出了一个新概念。不再使用合成网片（吊带）或填充剂（胶原蛋白、硅酮等）等异体材料；现在我们有了利用自体干细胞恢复功能的潜力。
