University of Manchester, Manchester M13 9PL, UK.
Stem Cells Int. 2012;2012:282348. doi: 10.1155/2012/282348. Epub 2011 Dec 19.
Tissue engineering is a pioneering field with huge advances in recent times. These advances are not only in the understanding of how cells can be manipulated but also in potential clinical applications. Thus, tissue engineering, when applied to skeletal muscle cells, is an area of huge prospective benefit to patients with muscle disease/damage. This could include damage to muscle from trauma and include genetic abnormalities, for example, muscular dystrophies. Much of this research thus far has been focused on satellite cells, however, mesenchymal stem cells have more recently come to the fore. In particular, results of trials and further research into their use in heart failure, stress incontinence, and muscular dystrophies are eagerly awaited. Although no doubt, stem cells will have much to offer in the future, the results of further research still limit their use.
组织工程是一个具有开创性的领域，近年来取得了巨大的进展。这些进展不仅在于对细胞如何进行操纵的理解，还在于潜在的临床应用。因此，将组织工程应用于骨骼肌细胞是一个具有巨大潜在益处的领域，可以使患有肌肉疾病/损伤的患者受益。这可能包括因创伤导致的肌肉损伤，以及例如肌肉营养不良等遗传异常。到目前为止，这项研究的大部分重点都放在卫星细胞上，然而，间充质干细胞最近也受到了关注。特别是，人们急切地期待着关于它们在心衰、压力性尿失禁和肌肉营养不良中的应用的临床试验和进一步研究的结果。尽管毫无疑问，干细胞在未来会有很大的贡献，但进一步研究的结果仍然限制了它们的应用。
