Neumann Frédéric, Diedhiou Abdoulaye, Sainte-Rose Danielle, Duvillard Pierre
Service d'anatomie pathologique, hôpital Pierre-Zobda-Quitman, BP 632, Fort-de-France, France.
Ann Pathol. 2010 Feb;30(1):33-5. doi: 10.1016/j.annpat.2009.12.002. Epub 2010 Feb 20.
Primary neuroendocrine carcinoma arises mainly in the gastrointestinal tract, lungs and pancreas, localization in the fallopian tube is exceptional with only one case being reported in literature. This second case concerns a 54-year-old patient, diagnosed at the Pierre-Zobda-Quitman hospital. Tumor histology revealed a poorly differentiated carcinoma with medium to large cells, marked atypia and high mitotic activity. Immunostaining was positive for chromogranine A, synaptophysine and CD56. Primary fallopian tube neuroendocrine carcinoma requires cross referencing of the radiological, pathological and immunohistochemical findings and discarding the differential diagnoses.
原发性神经内分泌癌主要发生于胃肠道、肺和胰腺，发生于输卵管者极为罕见，文献中仅报道过1例。本文报道的第2例为一名54岁患者，在皮埃尔 - 佐布达 - 奎特曼医院确诊。肿瘤组织学检查显示为低分化癌，细胞中到大，异型性明显，有丝分裂活性高。免疫组化染色嗜铬粒蛋白A、突触素和CD56呈阳性。原发性输卵管神经内分泌癌需要综合影像学、病理学和免疫组化检查结果，并排除鉴别诊断。
