输卵管神经内分泌肿瘤：病例系列报告及文献综述

Neuroendocrine Tumors of the Fallopian Tube: Report of a Case Series and Review of the Literature.

作者信息

Grondin Katherine, Lidang Marianne, Boenelycke Marie, Alvarado-Cabrero Isabel, Herrington C Simon, McCluggage W Glenn

机构信息

Pathology Department, L'Hôtel-Dieu de Québec, Centre Hospitalier Universitaire de Québec, Laval University, Quebec City, QC, Canada (K.G.) Pathology Department, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark (M.L., M.B.) Pathology Department, del Hospital de Oncología, Mexico City, Mexico (I.A.-C.) Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh Division of Pathology, Edinburgh, United Kingdom (C.S.H.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom (W.G.M.).

出版信息

Int J Gynecol Pathol. 2019 Jan;38(1):78-84. doi: 10.1097/PGP.0000000000000458.

DOI:10.1097/PGP.0000000000000458

PMID:29019870

Abstract

Primary neuroendocrine tumors of the fallopian tube are extremely rare with a few reported cases of high-grade neuroendocrine carcinoma and a single report of a carcinoid tumor arising in a teratoma. We report 4 cases of probable primary neuroendocrine tumors of the fallopian tube (2 carcinoid tumors/low-grade neuroendocrine tumors and 2 high-grade neuroendocrine carcinomas) in patients aged 49 to 71. These represent the first reported cases of primary tubal carcinoid tumor unassociated with a teratoma. We review the published literature regarding primary neuroendocrine tumors of the fallopian tube and speculate on the possible histogenesis of these neoplasms.

摘要

原发性输卵管神经内分泌肿瘤极为罕见，仅有少数高级别神经内分泌癌的病例报道，以及一例畸胎瘤中发生类癌肿瘤的单独报道。我们报告了4例年龄在49至71岁之间的可能的原发性输卵管神经内分泌肿瘤（2例类癌肿瘤/低级别神经内分泌肿瘤和2例高级别神经内分泌癌）。这些是首次报道的与畸胎瘤无关的原发性输卵管类癌肿瘤病例。我们回顾了关于原发性输卵管神经内分泌肿瘤的已发表文献，并推测了这些肿瘤可能的组织发生学。