Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India.
Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India.
Int J Cardiol. 2010 Nov 19;145(2):358-359. doi: 10.1016/j.ijcard.2010.02.034. Epub 2010 Mar 11.
Acute ingestion of large quantity of chili peppers (rich source of capsaicin) produced hypertensive crisis in a patient. The hypertensive response was explained on the basis of decreased vasodilator substance calcitonin gene-related peptide (CGRP) from sensory nerve terminals by capsaicin. Here we present our experimental observations in anaesthetized rats regarding the mechanisms underlying hypertensive response induced by capsaicin. Our results demonstrate non-involvement of adrenergic and angiotensinergic mechanisms and also the cardiac changes in producing the response. Thus, the direct action of capsaicin on vascular smooth muscle or the activation of endothelin is proposed.
大量摄入辣椒（富含辣椒素）会导致患者出现高血压危象。辣椒素会从感觉神经末梢减少血管舒张物质降钙素基因相关肽（CGRP），从而解释这种高血压反应。在这里，我们在麻醉大鼠中展示了我们关于辣椒素引起的高血压反应的机制的实验观察结果。我们的结果表明，肾上腺素能和血管紧张素能机制以及心脏变化都与产生这种反应无关。因此，提出了辣椒素对血管平滑肌的直接作用或内皮素的激活。
