The Royal Orthopaedic Hospital Oncology Service, Northfield, Birmingham, United Kingdom.
Cancer Treat Rev. 2010 Jun;36(4):342-7. doi: 10.1016/j.ctrv.2010.02.010. Epub 2010 Mar 12.
Primary malignant bone tumours are rare but are one of the most common malignancies in adolescents. The optimum management of a child with a bone tumour is at a specialist treatment centre by a multidisciplinary team experienced in the diagnosis, chemotherapy and surgical management of these conditions. Most tumours are treated with chemotherapy followed by surgery. The surgical aim is to completely resect the tumour whilst ideally preserving the limb and maintaining function. The perfect limb salvage operation that restores normal function with no long term morbidity is rarely possible and most operations will restore function with potential long term complications. The variety of techniques possible for limb salvage includes the use of prostheses, allografts, reimplantation of sterilised bone or use of vascularised bone. Extendible prostheses are now common place and can maintain limb length following tumour resection even in the young child. Assessing outcomes is notoriously difficult but various measures are starting to allow comparisons of long term outcomes for this group of patients.
原发性骨恶性肿瘤较为罕见，但却是青少年中最常见的恶性肿瘤之一。儿童骨肿瘤的最佳治疗方法是在专家治疗中心，由多学科团队进行，他们在这些疾病的诊断、化疗和手术管理方面经验丰富。大多数肿瘤采用化疗，然后手术。手术的目的是在理想情况下保留肢体和功能的同时，彻底切除肿瘤。完美的保肢手术可以恢复正常功能且无长期并发症，但很少能实现，大多数手术将恢复功能，但可能存在长期并发症。保肢的各种技术包括使用假体、同种异体移植物、再植入消毒骨或使用带血管骨。可延长假体现在很常见，即使在幼儿中，也可以在肿瘤切除后保持肢体长度。评估结果是众所周知的困难，但各种措施开始允许对这组患者的长期结果进行比较。
