Department of Emergency, Qilu Hospital of Shandong University, Jinan, China.
J Renin Angiotensin Aldosterone Syst. 2010 Jun;11(2):127-35. doi: 10.1177/1470320310364181. Epub 2010 Mar 11.
We performed a meta-analysis with the aim of assessing the association of the angiotensin II type 1 (AT(1)) receptor gene A1166C polymorphism with essential hypertension in Chinese case-control studies.
Studies were searched from the Chinese Biomedicine Database, the China National Knowledge Infrastructure platform, Pubmed and Medline, using the search terms 'hypertension', 'angiotensin II type 1 receptor', 'AT(1)R', 'polymorphism', 'China' and 'Chinese', without limiting to any specific language. The strength of the association between the A1166C polymorphism and hypertension was evaluated by the odds ratio (OR) with the corresponding 95% confidence interval (CI). The analyses were performed with Cochrane RevMan software version 4.2.
Overall, the variant genotype AC/CC was associated with a statistically increased essential hypertension risk with the pooled OR 1.48 (95% CI: 1.20-1.83). In the subgroup analyses, the association was also significant among studies using Northern populations, Southern populations, Han Chinese and hospital-based controls. The age did not influence the relationship between the AT( 1) receptor A1166C polymorphism and hypertension in the subgroup analyses.
The present meta-analysis suggests that the AT(1) receptor 1166 AC/CC genotype is associated with susceptibility to hypertension in the Chinese population.
我们进行了一项荟萃分析，旨在评估血管紧张素 II 型 1 (AT(1))受体基因 A1166C 多态性与中国病例对照研究中原发性高血压的相关性。
使用“高血压”、“血管紧张素 II 型 1 受体”、“AT(1)R”、“多态性”、“中国”和“中文”等检索词，在中国生物医学文献数据库、中国国家知识基础设施平台、Pubmed 和 Medline 中进行检索，未限制任何特定语言。使用 Cochrane RevMan 软件版本 4.2 评估 A1166C 多态性与高血压之间的关联强度，采用比值比 (OR) 及其相应的 95%置信区间 (CI)。
总体而言，变异基因型 AC/CC 与原发性高血压风险呈统计学上显著增加相关，合并 OR 为 1.48 (95% CI：1.20-1.83)。在亚组分析中，在使用北方人群、南方人群、汉族和医院为基础的对照组的研究中，这种关联也是显著的。年龄在亚组分析中并不影响 AT(1)受体 A1166C 多态性与高血压之间的关系。
本荟萃分析表明，AT(1)受体 1166 AC/CC 基因型与中国人群的高血压易感性相关。
