Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, PR China.
J Renin Angiotensin Aldosterone Syst. 2013 Jun;14(2):181-8. doi: 10.1177/1470320312447652. Epub 2012 May 29.
Angiotensin II type 1 receptor (AT1R) mediates the cardiovascular actions of angiotensin II. Growing studies have revealed the underlying association between AT1R-A1166C (rs5186) polymorphism and coronary heart disease (CHD) among the East Asia population.
from these studies remain conflicting. We conducted this meta-analysis to estimate the overall CHD risk of AT1R-A1166C polymorphism regarding the East Asia population. We searched the PubMed, Embase and China National Knowledge Infrastructure (CNKI) databases for all articles within a range of published years from 1995 to 2011. The odds ratio (OR) corresponding to the 95% confidence interval (CI) was used to assess the different associations. The statistical heterogeneity among studies was assessed with the Q-test and I (2) statistics. Up to December 2011, 17 case-control studies, including 2,366 cases and 2,414 controls, were available for our study. The C allele and the AC/CC genotypes were associated with significantly increased risk of CHD (OR = 1.59, 95% CI = 1.22-2.06 for C versus A and OR = 1.57, 95% CI = 1.16-2.13 for AC/CC versus AA, respectively). Our result suggested that AT1R-A1166C polymorphism may be involved in the development of CHD.
血管紧张素 II 型 1 型受体（AT1R）介导血管紧张素 II 的心血管作用。越来越多的研究揭示了东亚人群中 AT1R-A1166C（rs5186）多态性与冠心病（CHD）之间的潜在关联。
这些研究的结果仍存在争议。我们进行了这项荟萃分析，以评估东亚人群中 AT1R-A1166C 多态性与冠心病总体风险的关系。我们在 PubMed、Embase 和中国国家知识基础设施（CNKI）数据库中搜索了 1995 年至 2011 年出版的所有文章。使用相应的 95%置信区间（CI）的比值比（OR）来评估不同的关联。用 Q 检验和 I（2）统计来评估研究之间的统计异质性。截至 2011 年 12 月，共有 17 项病例对照研究，包括 2366 例病例和 2414 例对照，可供我们研究。C 等位基因和 AC/CC 基因型与冠心病的风险显著增加相关（C 对 A 的 OR=1.59，95%CI=1.22-2.06，AC/CC 对 AA 的 OR=1.57，95%CI=1.16-2.13）。我们的结果表明，AT1R-A1166C 多态性可能与 CHD 的发生有关。
