择期行乙状结肠切除术治疗憩室病的适应证。

Indications for elective sigmoid resection in diverticular disease.

机构信息

Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands.

出版信息

Ann Surg. 2010 Apr;251(4):670-4. doi: 10.1097/SLA.0b013e3181d3447d.

Abstract

INTRODUCTION

To prevent an acute surgery, classic indications for elective sigmoid resections concerning diverticulitis have usually been based on the number of recurrent episodes. Since 2005 these indications have been challenged, primarily because the majority of patients first present themselves with acute complications at their first episode.

METHODS

Between 1990 and 2000, a cohort analysis was conducted involving all patients admitted to the VU University Medical Center with the diagnosis of diverticulitis, with a follow-up until January 2009. To identify those patients who might benefit from elective sigmoid resection, several risk factors were analyzed.

RESULTS

Of 291 patients examined, 111 (38%) were treated conservatively and 180 (62%) underwent surgery, of which 108 acute and 72 elective. The conservatively treated episodes of diverticulitis showed a recurrence rate of 48% (88 patients). Indications for elective surgery were recurrent attacks of diverticulitis with persistent complaints (36%), complaints of stenosis (40%), fistula (14%), persistent abscesses (3%), and recurrent diverticular bleeding (7%). Of the 74% of the patients approached laparoscopically, the overall morbidity was 22% with no mortality. The main indication for an AO was perforation with general peritonitis, holding for 57% of the acutely operated patients. Other indications were abscesses (22%), stenosis with obstruction (11%), failure of conservative therapy (6%), or diverticular bleeding (4%). Hartmann's procedure was the most frequently performed procedure (58%). This acutely operated population was associated with high morbidity (56%) and mortality (13%), perforation leads to 10% mortality and other causes to 3%. Of those patients undergoing acute surgery, 20% had a history of diverticulitis. Moreover, risk factor analysis showed that those patients having one or more of the following indications: (1) using immunosuppression therapy, (2) having chronic renal failure, or (3) collagen-vascular diseases, had a significant 5-fold greater risk (36% vs. 7%) of a perforation in recurrent episodes of diverticulitis.

CONCLUSION

In the treatment of diverticular disease, indications for an elective sigmoid resection should not be based on the number of episodes only. Clear indications for elective sigmoid resections are complaints of stenosis, fistulas, or recurrent diverticular bleeding. Furthermore, an elective sigmoid resection might be justified in high-risk patients, after a conservatively treated episode of diverticulitis, who use immunosuppression therapy and have chronic renal failure or collagen-vascular diseases.

摘要

介绍

为了避免急性手术,经典的择期乙状结肠切除术的适应证通常基于疾病的反复发作次数。自 2005 年以来,这些适应证受到了挑战,主要是因为大多数患者首次发作时就出现了急性并发症。

方法

1990 年至 2000 年期间,对所有被诊断为憩室炎并在 VU 大学医学中心接受治疗的患者进行了队列分析,随访至 2009 年 1 月。为了确定哪些患者可能受益于择期乙状结肠切除术,分析了几个危险因素。

结果

在 291 名接受检查的患者中,111 名(38%)接受了保守治疗,180 名(62%)接受了手术治疗,其中 108 例为急性手术,72 例为择期手术。保守治疗的憩室炎发作的复发率为 48%(88 例)。择期手术的适应证为憩室炎反复发作且持续存在症状(36%)、狭窄症状(40%)、瘘管(14%)、持续脓肿(3%)和复发性憩室出血(7%)。接受腹腔镜手术的患者中,74%的总体发病率为 22%,无死亡病例。急性手术的主要适应证是穿孔合并弥漫性腹膜炎,占急性手术患者的 57%。其他适应证包括脓肿(22%)、狭窄伴梗阻(11%)、保守治疗失败(6%)或憩室出血(4%)。Hartmann 手术是最常进行的手术(58%)。该急性手术人群的发病率(56%)和死亡率(13%)均较高,穿孔导致 10%的死亡率,其他原因导致 3%的死亡率。在接受急性手术的患者中,20%有憩室炎病史。此外,危险因素分析表明,有以下一种或多种适应证的患者:(1)使用免疫抑制治疗;(2)患有慢性肾衰竭;(3)患有胶原血管疾病,其憩室炎反复发作穿孔的风险显著增加 5 倍(36%比 7%)。

结论

在治疗憩室疾病时,择期乙状结肠切除术的适应证不应仅基于发作次数。择期乙状结肠切除术的明确适应证为狭窄、瘘管或复发性憩室出血。此外,在接受保守治疗的憩室炎发作后,对于使用免疫抑制治疗、患有慢性肾衰竭或胶原血管疾病的高危患者,也可以考虑进行择期乙状结肠切除术。

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