Bayerl Martin, Dielentheis Thomas F, Vucurevic Goran, Gesierich Thomas, Vogel Friederike, Fehr Christoph, Stoeter Peter, Huss Michael, Konrad Andreas
Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg-University Mainz, Germany.
Neuroreport. 2010 Apr 21;21(6):442-6. doi: 10.1097/WNR.0b013e328338b9be.
Neuroimaging studies in attention-deficit/hyperactivity disorder (ADHD) have shown abnormalities in several brain areas including the frontostriatal circuitry and were mostly conducted in children and adolescents. We investigated 30 never-medicated adult ADHD patients (16 males) and 30 matched healthy control individuals. Functional magnetic resonance imaging was acquired during a working memory paradigm (n-back). Group activation maps and group differences of activation were calculated using voxel-based analyses. The generic activation pattern was more extended in the control group. In ADHD patients, significantly decreased activation was found in the right inferior parietal cortex. Disturbed parietal brain function may particularly contribute to inattention and working memory impairment in ADHD patients.
注意力缺陷多动障碍（ADHD）的神经影像学研究表明，包括额纹状体回路在内的多个脑区存在异常，且这些研究大多在儿童和青少年中进行。我们调查了30名从未接受过药物治疗的成年ADHD患者（16名男性）和30名匹配的健康对照个体。在工作记忆范式（n-back）期间采集功能磁共振成像。使用基于体素的分析计算组激活图和激活的组间差异。对照组的一般激活模式范围更广。在ADHD患者中，右侧顶下皮质的激活显著降低。顶叶脑功能紊乱可能尤其导致ADHD患者的注意力不集中和工作记忆受损。
Zotero 插件