Ehlis Ann-Christine, Bähne Christina G, Jacob Christian P, Herrmann Martin J, Fallgatter Andreas J
Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany.
J Psychiatr Res. 2008 Oct;42(13):1060-7. doi: 10.1016/j.jpsychires.2007.11.011. Epub 2008 Jan 28.
Near-infrared spectroscopy (NIRS) is an optical imaging method, which allows non-invasive in vivo measurements of changes in the concentration of oxygenated (O2Hb) and deoxygenated (HHb) haemoglobin in cortical tissue. For the present study, we examined 13 adult ADHD patients and 13 age- and gender-matched healthy controls by means of multi-channel NIRS (Optical Topography; ETG-100, Hitachi Medical Co., Japan) during performance of a working memory (n-back) paradigm. Compared to the healthy control group, ADHD patients showed reduced task-related increases in the concentration of O2Hb in NIRS channels located over the ventro-lateral prefrontal cortex, indicating reduced activation during performance of the n-back task in this part of the brain. This finding was particularly apparent for the task condition with high working memory load (2-back), and was accompanied by a statistical trend towards an increased number of omission errors in the patient group. The data confirm previous findings of working memory deficits and prefrontal cortex dysfunction in patients suffering from ADHD, and are discussed in the light of imaging findings and theoretical models of working memory function.
近红外光谱技术（NIRS）是一种光学成像方法，它能够对皮质组织中氧合血红蛋白（O2Hb）和脱氧血红蛋白（HHb）浓度的变化进行非侵入性活体测量。在本研究中，我们通过多通道近红外光谱技术（光学地形图；ETG - 100，日本日立医疗公司），在执行工作记忆（n - 回溯）范式期间，对13名成年注意力缺陷多动障碍（ADHD）患者和13名年龄及性别匹配的健康对照者进行了检查。与健康对照组相比，ADHD患者在腹外侧前额叶皮质上方的近红外光谱通道中，与任务相关的O2Hb浓度增加减少，这表明在执行n - 回溯任务期间，大脑的这一部分激活减少。这一发现对于高工作记忆负荷（2 - 回溯）的任务条件尤为明显，并且患者组中漏报错误数量有增加的统计趋势。这些数据证实了先前关于ADHD患者工作记忆缺陷和前额叶皮质功能障碍的研究结果，并根据工作记忆功能的成像结果和理论模型进行了讨论。
