Jungmichel Stephanie, Stucki Manuel
Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich, Switzerland.
Chromosoma. 2010 Aug;119(4):337-49. doi: 10.1007/s00412-010-0266-9. Epub 2010 Mar 12.
The chromatin structure is important for recognition and repair of DNA damage. Many DNA damage response proteins accumulate in large chromatin domains flanking sites of DNA double-strand breaks. The assembly of these structures-usually termed DNA damage foci-is primarily regulated by MDC1, a large nuclear mediator/adaptor protein that is composed of several distinct structural and functional domains. Here, we are summarizing the latest discoveries about the mechanisms by which MDC1 mediates DNA damage foci formation, and we are reviewing the considerable efforts taken to understand the functional implication of these structures.
染色质结构对于DNA损伤的识别和修复至关重要。许多DNA损伤反应蛋白聚集在DNA双链断裂位点两侧的大型染色质结构域中。这些结构（通常称为DNA损伤灶）的组装主要受MDC1调控，MDC1是一种大型核介质/衔接蛋白，由几个不同的结构和功能域组成。在此，我们总结了关于MDC1介导DNA损伤灶形成机制的最新发现，并回顾了为理解这些结构的功能意义所做的大量努力。
