Cao Jie, Wang Zhen-Hua, Jia Juan, Yun Ke-Ming, Wei Zhi-Wen, Wang Yu-Jin
School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Fa Yi Xue Za Zhi. 2009 Dec;25(6):434-6.
The stability of ketamine in biological samples was studied under different storage temperature and time.
The rabbits were given intragastric administration of ketamine with a dose of 150 mg/kg and were sacrificed after 30 minutes. Blood, liver, kidney and brain of the rabbits were stored at room temperature (between 18 degrees C and 24 degrees C) and -20 degrees C. The specimens were analyzed at different times by GC-MS and GC-NPD.
At -20 degrees C, the concentration of ketamine decreased in all of samples (P < 0.05) within 30 days. The concentration of ketamine increased in all of samples stored at room temperature after 5 days(P < 0.05).
The stability of ketamine in biological samples stored at -20 degrees C was better than that at room temperature. The samples suspected containing ketamine should be stored at -20 degrees C and should be tested as soon as possible.
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