Licata M, Pierini G, Popoli G
Institute of Legal Medicine, University of Modena, Italy.
J Forensic Sci. 1994 Sep;39(5):1314-20.
An unusual case of death by ketamine overdose is reported. The drug's administration was a homicide for homosexual ends. Authors discuss a rapid and effective solid-phase extraction procedure using Bond-Elute* C18 for Ketamine and Nor-Ketamine detection in biological fluids and tissues with a 75% recovery. The drug analysis was carried out by the means of gas-chromatography (GLC) and gas-chromatography/mass spectrometry (GC-MS). The yield of the procedure for Ketamine was: blood 27.4 micrograms/mL; urine 8.51 micrograms/mL; bile 15.2 micrograms/mL; brain 3.24 micrograms/mL; liver 6.6 micrograms/mL; kidney 3.38 micrograms/mL. Nor-Ketamine was detected in all samples, but not quantified.
报告了一例氯胺酮过量致死的罕见案例。该药物的施用是一起出于同性恋目的的杀人案件。作者讨论了一种快速有效的固相萃取程序，该程序使用Bond-Elute* C18在生物体液和组织中检测氯胺酮和去甲氯胺酮，回收率为75%。药物分析通过气相色谱法（GLC）和气相色谱/质谱法（GC-MS）进行。氯胺酮该程序的产量为：血液27.4微克/毫升；尿液8.51微克/毫升；胆汁15.2微克/毫升；大脑3.24微克/毫升；肝脏6.6微克/毫升；肾脏3.38微克/毫升。在所有样本中均检测到去甲氯胺酮，但未进行定量分析。
