Internal Medicine Department, Hospital Virgen del Camino, Sanlúcar de Barrameda, Cádiz, Spain.
Med Clin (Barc). 2010 May 15;134(14):617-23. doi: 10.1016/j.medcli.2009.07.055. Epub 2010 Mar 11.
The Chronic Kidney Disease Epidemiology Collaboration (CDK-EPI) equation has been proposed as a replacement for the Modification of Diet in Renal Disease (MDRD) equation to estimate the glomerular filtration rate, but this equation has not yet been evaluated in the general population.
Cross-sectional analysis of a random sample of 858 participants from the general population aged 50-75 years without known kidney disease. The prevalence of low eGFR (< 60 mL/min/1.73 m(2)) was assessed with the MDRD and the CKD-EPI equations in the overall sample and in normoalbuminuric individuals.
With the MDRD equation the median eGFRs (interquartile range) in men/women were 63.3(12.2)/56.7(9.4)mL/min/1.73 m(2), and with the CKD-EPI equation 66.6(14.2)/61.3(11.6) mL/min/1.73 m(2). The prevalence of low eGFR in men/women was 35.2%/68.5% and 25.1%/45.7% with the MDRD and the CKD-EPI equations, respectively. Normoalbuminuric women without risk factors for CKD experienced the most pronounced reduction in the number of cases with low eGFR with the CKD-EPI equation. The prevalence of renal impairment in this subgroup still remained even greater than that in men with diabetes, hypertension, or cardiovascular disease.
Compared with the MDRD, the CKD-EPI equation generates a substantial reduction in the prevalence of renal impairment in subjects with diabetes, hypertension, cardiovascular disease, and in subjects without risk factors. The prevalence of renal impairment in normoalbuminuric females may be still overestimated with the CKD-EPI equation.
慢性肾脏病流行病学协作组（CKD-EPI）方程已被提议取代改良肾脏病饮食研究（MDRD）方程来估计肾小球滤过率，但该方程尚未在普通人群中进行评估。
对一个无已知肾脏疾病的 50-75 岁普通人群的 858 名随机样本进行横断面分析。在整个样本和正常白蛋白尿个体中，用 MDRD 和 CKD-EPI 方程评估低 eGFR（<60 mL/min/1.73 m²）的患病率。
用 MDRD 方程，男性/女性的中位 eGFR（四分位间距）分别为 63.3（12.2）/56.7（9.4）mL/min/1.73 m²，用 CKD-EPI 方程为 66.6（14.2）/61.3（11.6）mL/min/1.73 m²。用 MDRD 和 CKD-EPI 方程，男性/女性的低 eGFR 患病率分别为 35.2%/68.5%和 25.1%/45.7%。无 CKD 危险因素的正常白蛋白尿女性，用 CKD-EPI 方程后，低 eGFR 病例数的减少最为明显。在这个亚组中，肾功能损害的患病率仍然大于糖尿病、高血压或心血管疾病男性。
与 MDRD 相比，CKD-EPI 方程在患有糖尿病、高血压、心血管疾病以及无危险因素的患者中，显著降低了肾功能损害的患病率。在正常白蛋白尿女性中，CKD-EPI 方程可能仍高估了肾功能损害的患病率。
