Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Trends Pharmacol Sci. 2010 May;31(5):212-20. doi: 10.1016/j.tips.2010.02.003. Epub 2010 Mar 11.
Since the discovery of NAD-dependent deacetylase activity of the silent information regulator-2 (SIR2) family ('sirtuins'), many exciting connections between protein deacetylation and energy metabolism have been revealed. The importance of sirtuins in the regulation of many fundamental biological responses to various nutritional and environmental stimuli has been firmly established. Sirtuins have also emerged as critical regulators for aging and longevity in model organisms. Their absolute requirement of NAD has revived an enthusiasm in the study of mammalian biosynthesis of NAD. Sirtuin-targeted pharmaceutical and nutriceutical interventions against age-associated diseases are also on the horizon. This review summarizes the recent progress in sirtuin research (particularly in mammalian sirtuin biology) and re-evaluates the connection between sirtuins, metabolism, and age-associated diseases (e.g., type-2 diabetes) to set a basis for the next ten years of sirtuin research.
自从发现沉默信息调节因子-2（SIR2）家族的 NAD 依赖性去乙酰化酶活性（“sirtuins”）以来，已经揭示了蛋白质去乙酰化作用与能量代谢之间的许多令人兴奋的联系。Sirtuins 在调节各种营养和环境刺激的许多基本生物学反应中的重要性已得到牢固确立。Sirtuins 也是模型生物中衰老和长寿的关键调节剂。它们对 NAD 的绝对需求重新激发了人们对哺乳动物 NAD 生物合成的研究热情。针对与年龄相关疾病的靶向 Sirtuin 药物和营养干预措施也即将出现。本文综述了最近 Sirtuin 研究的进展（特别是在哺乳动物 Sirtuin 生物学方面），并重新评估了 Sirtuins、代谢与与年龄相关疾病（如 2 型糖尿病）之间的联系，为未来十年的 Sirtuin 研究奠定了基础。
