正常与肿瘤发育中的蛋白质磷酸化。氨基甲酸乙酯诱导的肺肿瘤中依赖环磷酸腺苷的蛋白激酶活性。
Protein phosphorylation in normal and neoplastic development. Cyclic AMP-dependent protein kinase activity in urethane-induced pulmonary tumours.
作者信息
Malkinson A M, Gunderson T J, McSwigan C E
出版信息
Biochem J. 1977 Nov 15;168(2):319-21. doi: 10.1042/bj1680319.
Abstract
The cyclic AMP-dependent protein kinase specific activities of cytosol fractions from urethane-induced lung tumours and from normal mouse lung were determined. Both basal and cyclic AMP-stimulated activities in tumours were twofold higher than those of normal lung. Since neonatal and adult lung cytosols have identical kinase activities, the high activity in tumours appears to be a tumour-specific property.
摘要
测定了来自氨基甲酸乙酯诱导的肺肿瘤和正常小鼠肺的胞质溶胶组分的环磷酸腺苷依赖性蛋白激酶的比活性。肿瘤中的基础活性和环磷酸腺苷刺激的活性均比正常肺高两倍。由于新生和成年肺胞质溶胶具有相同的激酶活性，肿瘤中的高活性似乎是肿瘤特异性特性。
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Protein phosphorylation in normal and neoplastic development. Cyclic AMP-dependent protein kinase activity in urethane-induced pulmonary tumours.正常与肿瘤发育中的蛋白质磷酸化。氨基甲酸乙酯诱导的肺肿瘤中依赖环磷酸腺苷的蛋白激酶活性。
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