Department of Prosthodontics, Dental School Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
J Dent. 2010 Jun;38(6):443-50. doi: 10.1016/j.jdent.2010.03.003. Epub 2010 Mar 11.
Endpoints are normally used to assess the efficacy of clinical treatment. In studies of peri-implantitis therapy, "true" endpoints are preferred to "surrogate", because they can capture a substantial proportion of the effect of treatment on an outcome of interest, for example implant failure.
To assess the type of endpoints reported in the literature on peri-implantitis therapy, and their frequency of use.
An extensive literature search was conducted (Pubmed, Cochrane, and Lilacs databases up to and including October 2009) to retrieve randomised controlled trials and non-randomised studies. Grey literature and major dental journals were also searched for potential studies. A variable was regarded as an endpoint only when it was clearly stated as the objective of an investigation.
Fourteen studies are included in this review. Data on implant failure are presented solely as a consequence of peri-implantitis therapy, and not as an objective of an investigation. No true endpoint was described in any study on peri-implantitis. Mean pocket probing depth at implant, mean clinical attachment level at implant, and mean bleeding on probing (after pocket depth assessment) at implant were the three surrogate endpoints cited most often in the studies. More than 20 different clinical endpoints were described in the studies selected.
Reports did not reveal whether or not the therapy for peri-implantitis is useful for reducing the risk of implant failure. A consensus should be reached among dental researchers to standardise surrogate endpoints, and efforts should be made to validate these endpoints.
终点通常用于评估临床治疗的疗效。在种植体周围炎治疗的研究中，“真实”终点优于“替代”终点，因为它们可以捕捉到治疗对感兴趣的结果的影响的很大一部分，例如种植体失败。
评估种植体周围炎治疗文献中报告的终点类型及其使用频率。
进行了广泛的文献检索（Pubmed、Cochrane 和 Lilacs 数据库，截至 2009 年 10 月），以检索随机对照试验和非随机研究。还搜索了灰色文献和主要牙科期刊，以寻找潜在的研究。只有当变量明确表示为调查的目标时，才将其视为终点。
本综述纳入了 14 项研究。关于种植体失败的数据仅作为种植体周围炎治疗的结果呈现，而不作为调查的目标。在任何一项种植体周围炎研究中都没有描述真正的终点。在研究中最常提到的三个替代终点是种植体的平均探诊深度、种植体的平均临床附着水平和种植体的平均探诊出血（在探诊深度评估后）。在所选择的研究中，描述了 20 多个不同的临床终点。
报告没有揭示种植体周围炎的治疗是否有助于降低种植体失败的风险。牙科研究人员应达成共识，标准化替代终点，并努力验证这些终点。
