College of Mechanical Engineering and Applied Electronics Technology, Beijing University of Technology, Beijing 100124, China.
J Biomech. 2010 May 7;43(7):1337-42. doi: 10.1016/j.jbiomech.2010.01.009. Epub 2010 Mar 15.
There is still a considerable lack of quantitative information concerning the effects of stent structures on blood flow in an aneurismal cavity. In this paper, five virtual stents with different structures and wire cross-sections were designed for incorporation into the same patient-specific aneurysm model. Computational fluid dynamics simulations were performed so as to study how these five types of stents modified hemodynamic parameters. Numerical results demonstrated that the mean flow rate in the aneurismal cavity decreased the most in the model that used a stent with a rectangular wire cross-section, and that the wall shear stresses at the dome and neck of the aneurysm decreased more in models that used a stent with a circular wire cross-section or a spiral stent with a rectangular wire cross-section compared to other models. In addition, the wall pressure on the aneurysm increased slightly after implantation of the stent in all five models. This result differs from that previously published, and may help guide the design and assist clinicians in selecting an appropriate stent for treating cerebral aneurysms.
关于支架结构对动脉瘤腔内血流的影响,目前仍然缺乏大量定量信息。本文设计了 5 种具有不同结构和线材横截面的虚拟支架,用于同一患者特定的动脉瘤模型。进行了计算流体动力学模拟,以研究这 5 种支架如何改变血流动力学参数。数值结果表明,在使用矩形线材横截面的支架的模型中,动脉瘤腔内的平均流速降低最多,而在使用圆形线材横截面或矩形线材横截面的螺旋支架的模型中,动脉瘤穹顶和颈部的壁切应力比其他模型降低更多。此外,在所有 5 种模型中,支架植入后动脉瘤壁上的压力略有增加。这一结果与之前发表的结果不同,可能有助于指导支架的设计,并帮助临床医生选择合适的支架来治疗脑动脉瘤。