Radaelli A G, Augsburger L, Cebral J R, Ohta M, Rüfenacht D A, Balossino R, Benndorf G, Hose D R, Marzo A, Metcalfe R, Mortier P, Mut F, Reymond P, Socci L, Verhegghe B, Frangi A F
Computational Imaging Laboratory, Information and Communication Technologies Department, Universitat Pompeu Fabra, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain.
J Biomech. 2008 Jul 19;41(10):2069-81. doi: 10.1016/j.jbiomech.2008.04.035. Epub 2008 Jun 25.
This paper presents the results of the Virtual Intracranial Stenting Challenge (VISC) 2007, an international initiative whose aim was to establish the reproducibility of state-of-the-art haemodynamical simulation techniques in subject-specific stented models of intracranial aneurysms (IAs). IAs are pathological dilatations of the cerebral artery walls, which are associated with high mortality and morbidity rates due to subarachnoid haemorrhage following rupture. The deployment of a stent as flow diverter has recently been indicated as a promising treatment option, which has the potential to protect the aneurysm by reducing the action of haemodynamical forces and facilitating aneurysm thrombosis. The direct assessment of changes in aneurysm haemodynamics after stent deployment is hampered by limitations in existing imaging techniques and currently requires resorting to numerical simulations. Numerical simulations also have the potential to assist in the personalized selection of an optimal stent design prior to intervention. However, from the current literature it is difficult to assess the level of technological advancement and the reproducibility of haemodynamical predictions in stented patient-specific models. The VISC 2007 initiative engaged in the development of a multicentre-controlled benchmark to analyse differences induced by diverse grid generation and computational fluid dynamics (CFD) technologies. The challenge also represented an opportunity to provide a survey of available technologies currently adopted by international teams from both academic and industrial institutions for constructing computational models of stented aneurysms. The results demonstrate the ability of current strategies in consistently quantifying the performance of three commercial intracranial stents, and contribute to reinforce the confidence in haemodynamical simulation, thus taking a step forward towards the introduction of simulation tools to support diagnostics and interventional planning.
本文介绍了2007年虚拟颅内支架置入挑战赛（VISC）的结果。这是一项国际倡议，其目的是在特定个体的颅内动脉瘤（IA）支架模型中，确立先进血液动力学模拟技术的可重复性。IA是脑动脉壁的病理性扩张，由于破裂后蛛网膜下腔出血，其死亡率和发病率都很高。最近，作为血流转向器的支架置入已被视为一种有前景的治疗选择，它有可能通过减少血流动力学力的作用并促进动脉瘤血栓形成来保护动脉瘤。现有成像技术的局限性阻碍了对支架置入后动脉瘤血流动力学变化的直接评估，目前需要借助数值模拟。数值模拟还有助于在干预前进行个性化的最佳支架设计选择。然而，从当前文献来看，很难评估特定患者支架模型中血液动力学预测的技术进步水平和可重复性。2007年VISC倡议致力于开发一个多中心对照基准，以分析不同网格生成和计算流体动力学（CFD）技术所引起的差异。该挑战赛还提供了一个机会，来调查目前学术和工业机构的国际团队在构建带支架动脉瘤计算模型时所采用的现有技术。结果表明，当前策略有能力持续量化三种商用颅内支架的性能，并有助于增强对血液动力学模拟的信心，从而朝着引入支持诊断和介入规划的模拟工具迈出了一步。
