联合病毒：抗肿瘤的溶瘤联合治疗！

United virus: the oncolytic tag-team against cancer!

机构信息

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6.

出版信息

Cytokine Growth Factor Rev. 2010 Apr-Jun;21(2-3):205-11. doi: 10.1016/j.cytogfr.2010.02.008. Epub 2010 Mar 12.

DOI:10.1016/j.cytogfr.2010.02.008

PMID:20227326

Abstract

There is an urgent need for innovative therapeutic strategies to treat aggressive metastatic cancers that are incurable with standard therapeutic approaches. Novel treatment strategies like oncolytic virotherapy have led, in some cases, to impressive effects on disease progression in human trials, suggesting that approval of an oncolytic virus therapeutic is on the horizon. While combinations of oncolytic viruses with small molecules are already being tested and have shown promise, we propose that even greater therapeutic synergies could be achieved through rational design of complementary virus therapeutics. In this review, we discuss rational chemical and biological combination strategies to enhance oncolytic virotherapy highlighting the promising combination of vaccinia and vesicular stomatitis oncolytic viruses.

摘要

目前迫切需要创新的治疗策略来治疗用标准治疗方法无法治愈的侵袭性转移性癌症。新型治疗策略，如溶瘤病毒治疗，在某些情况下，在人体试验中对疾病进展产生了令人印象深刻的效果，这表明溶瘤病毒治疗药物的批准即将到来。虽然溶瘤病毒与小分子的联合治疗已经在进行测试并显示出前景，但我们认为，通过合理设计互补的病毒治疗药物，可以实现更大的治疗协同作用。在这篇综述中，我们讨论了增强溶瘤病毒治疗的合理化学和生物学联合策略，重点介绍了痘苗和水疱性口炎溶瘤病毒的有前途的联合。