Department of Pathology and Immunology, CMU, University of Geneva, Geneva, Switzerland.
FEBS Lett. 2010 Apr 16;584(8):1437-42. doi: 10.1016/j.febslet.2010.03.014. Epub 2010 Mar 15.
Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial carriers. Here, we highlight recent findings regarding UCP2 function in the immune system. UCP2 controls immune cell activation by modulating MAPK pathways and the production of mitochondrial reactive oxygen species. In several models of infection, inflammation and autoimmunity, a regulatory impact of UCP2 was demonstrated by its direct implication in the production of cytokines and nitric oxide and in cell migration. In addition, UCP2 is reported as a key protein for oxidation of fatty acids, glutamine and glucose. Therefore we present a model of how the regulation of nutrient oxidation by UCP2 promotes immune cell activation.
解偶联蛋白 2（UCP2）属于线粒体载体家族。在这里，我们重点介绍 UCP2 在免疫系统中的功能的最新发现。UCP2 通过调节 MAPK 途径和线粒体活性氧的产生来控制免疫细胞的激活。在几种感染、炎症和自身免疫模型中，UCP2 通过其直接参与细胞因子和一氧化氮的产生以及细胞迁移而显示出对免疫的调节作用。此外，UCP2 被报道为脂肪酸、谷氨酰胺和葡萄糖氧化的关键蛋白。因此，我们提出了一个模型，说明 UCP2 如何调节营养物质的氧化来促进免疫细胞的激活。
